Journal ArticleDOI
Impact of Sepsis on Neurodevelopmental Outcome in a Swiss National Cohort of Extremely Premature Infants
Luregn J. Schlapbach,Maude Aebischer,Mark Raymond Adams,Giancarlo Natalucci,Jan Bonhoeffer,Philipp Latzin,Mathias Nelle,Hans Ulrich Bucher,Beatrice Latal +8 more
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TLDR
Proven sepsis significantly contributes to NDI in extremely preterm infants, independent of other risk factors, and better strategies aimed at reducing the incidence of Sepsis in this highly vulnerable population are needed.Abstract:
Neonatal sepsis causes high mortality and morbidity in preterm infants, but less is known regarding the long-term outcome after sepsis. This study aimed to determine the impact of sepsis on neurodevelopment at 2 years' corrected age in extremely preterm infants.read more
Citations
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Journal ArticleDOI
The role of inflammation in perinatal brain injury
Henrik Hagberg,Henrik Hagberg,Carina Mallard,Donna M. Ferriero,Susan J. Vannucci,Steven W. Levison,Zinaida S. Vexler,Pierre Gressens +7 more
TL;DR: Important differences in innate and adaptive immunity in immature versus adult brain are highlighted, which support the notion that the consequences of inflammation will be entirely different depending on context and stage of CNS development.
Journal ArticleDOI
Mortality and Neonatal Morbidity Among Infants 501 to 1500 Grams From 2000 to 2009
Jeffrey D. Horbar,Joseph H. Carpenter,Gary J. Badger,Michael J. Kenny,Roger F. Soll,Kate A. Morrow,Jeffrey S. Buzas +6 more
TL;DR: Mortality and major neonatal morbidity in survivors decreased for infants with birth weight 501 to 1500 g between 2000 and 2009, however, at the end of the decade, a high proportion of these infants still either died or survived after experiencing ≥1 major neonnatal morbidity known to be associated with both short- and long-term adverse consequences.
Journal ArticleDOI
Mortality related to invasive infections, sepsis, and septic shock in critically ill children in Australia and New Zealand, 2002-13: a multicentre retrospective cohort study.
Luregn J. Schlapbach,Luregn J. Schlapbach,Lahn Straney,Janet Alexander,Graeme MacLaren,Graeme MacLaren,Graeme MacLaren,Marino Festa,Andreas Schibler,Andreas Schibler,Anthony Slater +10 more
TL;DR: Severe infections remain a major cause of mortality in paediatric ICUs, representing a major public health problem, and future studies should focus on patients with the highest risk of poor outcome, and assess the effectiveness of present sepsis interventions in children.
Journal ArticleDOI
Neonatal sepsis: Progress towards improved outcomes
Andi L. Shane,Barbara J. Stoll +1 more
TL;DR: In this article, the authors have identified Gram-negative pathogens as an emerging etiology of early-onset invasive infections, such as Group B streptococcal colonization, prolonged rupture of membranes, and intra-amniotic infection.
Journal ArticleDOI
Epidemiology of bronchopulmonary dysplasia
TL;DR: The diagnostic criteria, incidence, risk factors, and long-term outcomes ofBronchopulmonary dysplasia are summarized, including chronic respiratory impairment and neurodevelopmental delay.
References
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Journal ArticleDOI
Development and reliability of a system to classify gross motor function in children with cerebral palsy
Robert J. Palisano,Peter Rosenbaum,Stephen D. Walter,Dianne J Russell,Ellen Wood,Barbara Galuppi +5 more
TL;DR: A five‐level classification system analogous to the staging and grading systems used in medicine, which has application for clinical practice, research, teaching, and administration is developed.
Journal ArticleDOI
Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging
Martin J. Bell,Jessie L. Ternberg,Ralph D. Feigin,James P. Keating,Richard Marshall,Leslie L. Barton,Thomas Brotherton +6 more
TL;DR: These studies support the use of combination antimicrobial therapy in the treatment of infants with NEC and suggest vigorous diagnostic and supportive measures are appropriate for Stage I infants.
Journal ArticleDOI
Late-Onset Sepsis in Very Low Birth Weight Neonates: The Experience of the NICHD Neonatal Research Network
Barbara J. Stoll,Nellie I. Hansen,Avroy A. Fanaroff,Linda L. Wright,Waldemar A. Carlo,Richard A. Ehrenkranz,James A. Lemons,Edward F. Donovan,Ann R. Stark,Jon E. Tyson,William Oh,Charles R. Bauer,Sheldon B. Korones,Seetha Shankaran,Abbot R. Laptook,David K. Stevenson,Lu Ann Papile,W. Kenneth Poole +17 more
TL;DR: Infants who developed late-onset sepsis had a significantly prolonged hospital stay and were significantly more likely to die than those who were uninfected, especially if they were infected with Gram-negative organisms or fungi.
Journal ArticleDOI
Neurologic and Developmental Disability at Six Years of Age after Extremely Preterm Birth
TL;DR: Among extremely preterm children, cognitive and neurologic impairment is common at school age and a comparison with their classroom peers indicates a level of impairment that is greater than is recognized with the use of standardized norms.
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Late-Onset Sepsis in Very Low Birth Weight Neonates: The Experience of the NICHD Neonatal Research Network
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