Impact of the Coronavirus (COVID-19) pandemic on surgical practice - Part 2 (surgical prioritisation).
TL;DR: With guidelines specific to each specialty being implemented and followed, surgeons should be able to continue to provide safe and effective care to their patients during the COVID-19 pandemic.
About: This article is published in International Journal of Surgery.The article was published on 2020-05-12 and is currently open access. It has received 165 citations till now. The article focuses on the topics: Surgical Specialty & Specialty.
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TL;DR: This paper attempts to compartmentalise leadership aspects, allowing a closer examination of reports and the analysis of outcomes, to formulate a number of evidence-based recommendations on the de-escalation of restrictions.
105 citations
Cites background from "Impact of the Coronavirus (COVID-19..."
...summarise the effects of the pandemic on surgical practice worldwide (27,28)....
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TL;DR: In this paper, the authors provide a comprehensive and critical evaluation of the impact of the COVID-19 pandemic on scientific research and funding, as well as academic medical and surgical training.
78 citations
TL;DR: The temporary halt of the national screening program for breast cancer in the Netherlands has resulted in fewer surgical procedures over time and a pronounced decrease in the lower tumor stages that were operated on.
45 citations
Cites background from "Impact of the Coronavirus (COVID-19..."
...recommended postponing or not performing these procedures during the pandemic.(23,24,28,29) However, we found no increase in postoperative complications in the patients undergoing breast cancer surgery during the COVID-19 pandemic in our study....
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...In addition, this advice was given to reduce the risk of postoperative complications in patients with COVID-19 and to reduce the risk of spreading the disease.(23,24) As in other countries, in the Netherlands, the authorities recommended only performing essential surgery....
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TL;DR: In this article, the authors have emphasized exploring the ethical dilemmas that are faced by the public health care sectors across the globe, in fighting the COVID-19 pandemic situations in the current period.
35 citations
TL;DR: Since the first report of coronavirus commonly termed as COVID-19 in China, it has progressed into a pandemic and Italy has been one of the countries worst hit.
Abstract: Since the first report of coronavirus commonly termed as COVID-19 in China, it has progressed into a pandemic and Italy has been one of the countries worst hit. Coronaviruses are enveloped ribonucleic acid (RNA) viruses that cause respiratory, entero-hepatic, and neurologic diseases in humans and mammals. More specifically the coronavirus causing the current pandemic is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The common symptoms include a dry continuous cough, fever and shortness of breath; severe cases involve pneumonia which may require ventilatory support.
32 citations
References
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TL;DR: A status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across 20 world regions.
Abstract: This article provides a status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across 20 world regions There will be an estimated 181 million new cancer cases (170 million excluding nonmelanoma skin cancer) and 96 million cancer deaths (95 million excluding nonmelanoma skin cancer) in 2018 In both sexes combined, lung cancer is the most commonly diagnosed cancer (116% of the total cases) and the leading cause of cancer death (184% of the total cancer deaths), closely followed by female breast cancer (116%), prostate cancer (71%), and colorectal cancer (61%) for incidence and colorectal cancer (92%), stomach cancer (82%), and liver cancer (82%) for mortality Lung cancer is the most frequent cancer and the leading cause of cancer death among males, followed by prostate and colorectal cancer (for incidence) and liver and stomach cancer (for mortality) Among females, breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death, followed by colorectal and lung cancer (for incidence), and vice versa (for mortality); cervical cancer ranks fourth for both incidence and mortality The most frequently diagnosed cancer and the leading cause of cancer death, however, substantially vary across countries and within each country depending on the degree of economic development and associated social and life style factors It is noteworthy that high-quality cancer registry data, the basis for planning and implementing evidence-based cancer control programs, are not available in most low- and middle-income countries The Global Initiative for Cancer Registry Development is an international partnership that supports better estimation, as well as the collection and use of local data, to prioritize and evaluate national cancer control efforts CA: A Cancer Journal for Clinicians 2018;0:1-31 © 2018 American Cancer Society
58,675 citations
TL;DR: Despite rigorous global containment and quarantine efforts, the incidence of COVID-19 continues to rise, with 90,870 laboratory-confirmed cases and over 3,000 deaths worldwide.
4,124 citations
"Impact of the Coronavirus (COVID-19..." refers background in this paper
...5 million cases and over 300,000 deaths brings new challenges for the international medical and surgical community [1]; the unprecedented...
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TL;DR: Analysis of the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Italy might help political leaders and health authorities to allocate enough resources, including personnel, beds, and intensive care facilities, to manage the situation in the next few days and weeks.
2,470 citations
"Impact of the Coronavirus (COVID-19..." refers background in this paper
...4 million cases and over 165,000 deaths brings new challenges for the international medical and surgical community [1]; the unprecedented strain it has put on units around the world has unfortunately been accompanied by an increasing number of COVID-19 infections and subsequent deaths amongst medical colleagues [2]....
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TL;DR: This study constructed a risk map indicating the vulnerability of different organs to 2019-nCoV infection, and identified the organs at risk, such as lung, heart, esophagus, kidney, bladder, and ileum, and located specific cell types (i.e., type II alveolar cells (AT2), myocardial cells, proximal tubule cells of the kidney, ileal cells, and bladder urothelial cells).
Abstract: It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2). Moreover, lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infection. However, some patients also exhibit non-respiratory symptoms, such as kidney failure, implying that 2019-nCoV could also invade other organs. To construct a risk map of different human organs, we analyzed the single-cell RNA sequencing (scRNA-seq) datasets derived from major human physiological systems, including the respiratory, cardiovascular, digestive, and urinary systems. Through scRNA-seq data analyses, we identified the organs at risk, such as lung, heart, esophagus, kidney, bladder, and ileum, and located specific cell types (i.e., type II alveolar cells (AT2), myocardial cells, proximal tubule cells of the kidney, ileum and esophagus epithelial cells, and bladder urothelial cells), which are vulnerable to 2019-nCoV infection. Based on the findings, we constructed a risk map indicating the vulnerability of different organs to 2019-nCoV infection. This study may provide potential clues for further investigation of the pathogenesis and route of 2019-nCoV infection.
1,809 citations
"Impact of the Coronavirus (COVID-19..." refers background in this paper
...Moreover, there is some evidence that SARS-CoV-2 especially targets the cells of the urinary tract as they strongly express angiotensinconverting enzyme 2 receptors - a known method of entry into the human host [43]....
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TL;DR: The clearance time and factors influencing 2019 novel coronavirus (2019-nCoV) RNA in different samples from patients with COVID-19 were analyzed, providing further evidence to improve the management of patients during convalescence and showed that the CD4+ T lymphocyte count may help predict the duration of viral RNA detection in patients’ stools.
Abstract: Background:
A patient's infectivity is determined by the presence of the virus in different body fluids, secretions, and excreta. The persistence and clearance of viral RNA from different specimens of patients with 2019 novel coronavirus disease (COVID-19) remain unclear. This study analyzed the clearance time and factors influencing 2019 novel coronavirus (2019-nCoV) RNA in different samples from patients with COVID-19, providing further evidence to improve the management of patients during convalescence.
724 citations
"Impact of the Coronavirus (COVID-19..." refers background in this paper
...Additionally, whilst the extent of urinary viral shedding is not yet fully understood, there is some early evidence that SARS-CoV-2 Viral RNA is detectable in urine suggesting precautions must still be undertaken in urological services [42]....
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