Impact of the tumor microenvironment on prognosis in follicular lymphoma is dependent on specific treatment protocols
Citations
62 citations
61 citations
58 citations
56 citations
Cites background from "Impact of the tumor microenvironmen..."
...One study has suggested that different chemotherapy regimens may alter the prognostic impact of some markers in the tumour microenvironment (de Jong et al, 2009) and, as previously discussed, rituximab may modulate the impact of macrophages in FL (Taskinen et al, 2007; Canioni et al, 2008;…...
[...]
53 citations
Additional excerpts
...manual Median percent of cores across labs (range) Image=manual 38 (32-43) 61 (43-73) 65 (17-78)*** Among missclassified: Image<manual 23 (8-67) 67 (10-100) 0 (0-80) Image>manual 77 (33-92) 33 (0-80) 100 (20-100)...
[...]
...Manual score distribution Median percent of cores in each category across labs (range) 0-5% 0 (0-13)* 0 (0-21)* 17 (0-63) 6-25% 25 (13-38) 33 (25-63) 75 (29-88) 26-50% 46 (17-63) 46 (38-63) 0 (0-33)** >50% 17 (13-67) 13 (8-21) 4 (4-4)...
[...]
...manual Median percent of cores across labs (range) Flow=manual 50 (30-68) 38 (30-58) 71 (39-87) Among misclassified: Flow<manual 70 (38-100) 87 (50-90) 100 (10-100) Flow>manual 30 (0-54) 13 (10-50) 0 (0-90)...
[...]
References
1,459 citations
1,336 citations
"Impact of the tumor microenvironmen..." refers background in this paper
...From a biological point of view, the clinical behavior of FL is determined principally by the tumor microenvironment rather than by inherent properties of the tumor cells themselves.(5-7) Specific T-cell and accessory cell populations, including macrophages and follicular dendritic cells, have been reported to have an influence on overall and/or progression-free survival, either as a poor or a good prognostic parameter....
[...]
...haematologica | 2009; 94(1) | 75 | tance of the microenvironment in the clinical behavior of FL.(5-7) The precise nature of the relevant cell populations is still unclear, and published data on the prognostic significance of cell populations, including T-cell subsets, macrophages and follicular dendritic cells, are conflicting....
[...]
927 citations
"Impact of the tumor microenvironmen..." refers background in this paper
...It has been shown that fludarabine has a rather specific effect on FoxP3-positive regulatory T cells in patients with B-cell chronic lymphocytic leukemia, in that both the frequency and the inhibitory functions of these cells are reduced after treatment.(23-25) Very likely, interference with the tumor microenvironment may result in different responses depending on the specific role of the microenvironment in a specific class of FL....
[...]
889 citations
"Impact of the tumor microenvironmen..." refers background in this paper
...Similar effects of cyclophosphamide have been shown on regulatory T cells too.(26)...
[...]
863 citations