Impaired innate interferon induction in severe therapy resistant atopic asthmatic children.
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...Delayed IFN production could result from reduced antigen recognition, as has been reported in samples from children with severe asthma where reduced TLR3, RIG, and MDA5 expression were observed (30)....
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...This contrasts with previous data in monolayer cultures, which reported increased viral replication in cells isolated from donors with respiratory disease following high MOI RV infection (19, 23, 24, 30)....
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44 citations
Cites background from "Impaired innate interferon inductio..."
...In adults suffering from mild/moderately severe atopic asthma and in bronchial epithelial cells of children with severe therapy-refractory atopic asthma, a defective induction of type-1 interferon (IFN-β) and type-III interferon (IFN-λ) was found [136]....
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"Impaired innate interferon inductio..." refers background in this paper
...Array studies(22) have not found that these pattern recognition receptors are poorly expressed in asthma, and large genotyping studies have not highlighted any single-nucleotide polymorphisms associated with asthma for these genes.(41,42) These receptors also activate signaling pathways that are also common for pro-inflammatory cytokines,(18) which are not consistently reduced in studies where impaired IFN are observed....
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