Impaired innate interferon induction in severe therapy resistant atopic asthmatic children.
Michael R. Edwards,Nicolas Regamey,Marjolaine Vareille,Elisabeth Kieninger,Atul Gupta,Amelia Shoemark,Sejal Saglani,A Sykes,J Macintyre,Jane C. Davies,C Bossley,Andrew Bush,Sebastian L. Johnston +12 more
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TLDR
It is shown that compared with non-allergic healthy control children, bronchial epithelial cells cultured ex vivo from severe therapy resistant atopic asthmatic children have profoundly impaired interferon-β and interferons-λ mRNA and protein in response to rhinovirus (RV) and polyIC stimulation, and this is a feature of STRA.About:
This article is published in Mucosal Immunology.The article was published on 2013-07-01 and is currently open access. It has received 189 citations till now. The article focuses on the topics: Interferon.read more
Citations
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Journal ArticleDOI
House dust mite impairs antiviral response in asthma exacerbation models through its effects on TLR3.
TL;DR: Allergy is a known risk factor for viral‐induced asthma exacerbation, but little is known whether allergens may affect interferon responses.
Journal ArticleDOI
M1-like macrophages are potent producers of anti-viral interferons and M1-associated marker-positive lung macrophages are decreased during rhinovirus-induced asthma exacerbations.
A A Nikonova,Musa Khaitov,David A. Jackson,David A. Jackson,Stephanie Traub,Maria-Belen Trujillo-Torralbo,Maria-Belen Trujillo-Torralbo,Dmitriy A. Kudlay,Anton S. Dvornikov,Ajerico del-Rosario,Ajerico del-Rosario,Rudolf Valenta,Luminita A. Stanciu,Rahim Khaitov,Sebastian L. Johnston,Sebastian L. Johnston +15 more
TL;DR: Human M1-like BAL Mф are likely important contributors to anti-viral immunity and their numbers are reduced in patients with allergic asthma during RV-induced asthma exacerbations.
Journal ArticleDOI
Interferon response to respiratory syncytial virus by bronchial epithelium from children with asthma is inversely correlated with pulmonary function
Matthew C. Altman,Matthew C. Altman,Stephen R. Reeves,Stephen R. Reeves,Andrew R. Parker,Elizabeth Whalen,Kira Misura,Kaitlyn A Barrow,Richard G. James,Teal S. Hallstrand,Steven F. Ziegler,Jason S. Debley,Jason S. Debley +12 more
TL;DR: It is suggested that an exaggerated interferon response to viral infection by airway epithelial cells may be a mechanism leading to lung function decline in a subset of children with asthma.
Journal ArticleDOI
Impaired type I and type III interferon induction and rhinovirus control in human cystic fibrosis airway epithelial cells
Marjolaine Vareille,Elisabeth Kieninger,Marco P. Alves,Brigitte S. Kopf,Alexander Möller,Thomas Geiser,Sebastian L. Johnston,Michael R. Edwards,Nicolas Regamey +8 more
TL;DR: Evidence of deliberate manipulation of experimental data by the first author Dr M. Vareille is found and the paper is retracted, with an apology to the readers of Thorax and to the scientific community for the inconvenience this has caused.
Journal ArticleDOI
Patient stratification and the unmet need in asthma.
Linda Swedin,Tiiu Saarne,Maria Rehnberg,Pernilla Glader,Magdalena Niedzielska,Gustav Johansson,Petra Hazon,Matthew C. Catley +7 more
TL;DR: The current thinking on patient stratification in asthma is examined and the identification of the T2-high subset is looked at, which will represent the new unmet medical need now that the T1-high-targeting therapies have made it to the market.
References
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Journal ArticleDOI
A diverse range of gene products are effectors of the type I interferon antiviral response
John W. Schoggins,Sam J. Wilson,Maryline Panis,Mary Murphy,Christopher T. Jones,Paul D. Bieniasz,Charles M. Rice +6 more
TL;DR: It is shown that different viruses are targeted by unique sets of ISGs, and that each viral species is susceptible to multiple antiviral genes, which together encompass a range of inhibitory activities.
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Community study of role of viral infections in exacerbations of asthma in 9-11 year old children.
Sebastian L. Johnston,Philip Pattemore,G. Sanderson,Sandra Smith,F Lampe,Lynn Josephs,P. Symington,S. O'Toole,S. H. Myint,D. A. J. Tyrrell +9 more
TL;DR: This study supports the hypothesis that upper respiratory viral infections are associated with 80-85% of asthma exacerbations in school age children.
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A large-scale, consortium-based genomewide association study of asthma.
Miriam F. Moffatt,Ivo Gut,Florence Demenais,David P. Strachan,Emmanuelle Bouzigon,Simon Heath,Erika von Mutius,Martin Farrall,Mark Lathrop,William O.C.M. Cookson +9 more
TL;DR: A few common alleles are associated with disease risk at all ages and suggest a role for communication of epithelial damage to the adaptive immune system and activation of airway inflammation in asthma.
Journal ArticleDOI
IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.
Sergei V. Kotenko,Grant Gallagher,Vitaliy V. Baurin,Anita Lewis-Antes,Meiling Shen,Nital K. Shah,Jerome A. Langer,Faruk Sheikh,Harold Dickensheets,Raymond P. Donnelly +9 more
TL;DR: The identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state and may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs.
Journal ArticleDOI
Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group
Romain Pauwels,Claes-Göran Löfdahl,Dirkje S. Postma,Anne E. Tattersfield,Paul M. O'Byrne,Peter J. Barnes,A Ullman +6 more
TL;DR: In patients who have persistent symptoms of asthma despite treatment with inhaled glucocorticoids, the addition of formoterol to budesonid therapy or the use of a higher dose of budesonide may be beneficial.
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