Impaired innate interferon induction in severe therapy resistant atopic asthmatic children.
Michael R. Edwards,Nicolas Regamey,Marjolaine Vareille,Elisabeth Kieninger,Atul Gupta,Amelia Shoemark,Sejal Saglani,A Sykes,J Macintyre,Jane C. Davies,C Bossley,Andrew Bush,Sebastian L. Johnston +12 more
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TLDR
It is shown that compared with non-allergic healthy control children, bronchial epithelial cells cultured ex vivo from severe therapy resistant atopic asthmatic children have profoundly impaired interferon-β and interferons-λ mRNA and protein in response to rhinovirus (RV) and polyIC stimulation, and this is a feature of STRA.About:
This article is published in Mucosal Immunology.The article was published on 2013-07-01 and is currently open access. It has received 189 citations till now. The article focuses on the topics: Interferon.read more
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Interferon response of the cystic fibrosis bronchial epithelium to major and minor group rhinovirus infection
Aline Schögler,Aline Schögler,Andrea Stokes,Andrea Stokes,Carmen Casaulta,Nicolas Regamey,Michael R. Edwards,Sebastian L. Johnston,Andreas Jung,Alexander Moeller,Thomas Geiser,Thomas Geiser,Marco P. Alves,Marco P. Alves +13 more
TL;DR: In a pilot study, the antiviral response of CF and healthy bronchial epithelial cells (BECs) to RV infection was assessed and the IFN pathway induction upon minor group RVs infection was significantly increased at the level of IFNs and PRRs in CF BECs compared to healthy B ECs.
Journal ArticleDOI
Viruses and asthma: the role of common respiratory viruses in asthma and its potential meaning for SARS-CoV-2.
TL;DR: It is of crucial importance to revise the available scientific literature regarding the association between common respiratory viruses and asthma, as well as the newly emerging data about the molecular mechanisms of SARS‐CoV‐2 infection and its possible relation with asthma, to better understand the interrelation between common virus and asthma.
Journal ArticleDOI
Innate Immune Response to Viral Infections in Primary Bronchial Epithelial Cells is Modified by the Atopic Status of Asthmatic Patients.
Sylwia Moskwa,Wojciech J. Piotrowski,Jerzy Marczak,Małgorzata Pawełczyk,Anna Lewandowska-Polak,Marzanna Jarzębska,Małgorzata Brauncajs,Anna Głobińska,Paweł Górski,Nikolaos G. Papadopoulos,Michael R. Edwards,Sebastian L. Johnston,Marek L. Kowalski +12 more
TL;DR: The immune response of HBECs to virus infections may not be deficient in asthmatics, but seems to be modified by atopic status.
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Innate immunity as the orchestrator of allergic airway inflammation and resolution in asthma.
TL;DR: Existing knowledge on innate immune responses involved in allergic airway inflammation are outlined, current gaps in understanding of the underlying molecular and cellular mechanisms are highlighted and the potential use of innate effector cells in new therapeutic avenues are discussed.
Journal ArticleDOI
Severe Asthma in School-Age Children: Evaluation and Phenotypic Advances
TL;DR: Current knowledge of severe asthma in school-age children (age 6–17 years) with a focus on recent literature published after January 2012 is reviewed, as well as current phenotyping efforts and emerging phenotypic-directed therapies that may be of benefit for subpopulations of children with severe Asthma in the future.
References
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Journal ArticleDOI
A diverse range of gene products are effectors of the type I interferon antiviral response
John W. Schoggins,Sam J. Wilson,Maryline Panis,Mary Murphy,Christopher T. Jones,Paul D. Bieniasz,Charles M. Rice +6 more
TL;DR: It is shown that different viruses are targeted by unique sets of ISGs, and that each viral species is susceptible to multiple antiviral genes, which together encompass a range of inhibitory activities.
Journal ArticleDOI
Community study of role of viral infections in exacerbations of asthma in 9-11 year old children.
Sebastian L. Johnston,Philip Pattemore,G. Sanderson,Sandra Smith,F Lampe,Lynn Josephs,P. Symington,S. O'Toole,S. H. Myint,D. A. J. Tyrrell +9 more
TL;DR: This study supports the hypothesis that upper respiratory viral infections are associated with 80-85% of asthma exacerbations in school age children.
Journal ArticleDOI
A large-scale, consortium-based genomewide association study of asthma.
Miriam F. Moffatt,Ivo Gut,Florence Demenais,David P. Strachan,Emmanuelle Bouzigon,Simon Heath,Erika von Mutius,Martin Farrall,Mark Lathrop,William O.C.M. Cookson +9 more
TL;DR: A few common alleles are associated with disease risk at all ages and suggest a role for communication of epithelial damage to the adaptive immune system and activation of airway inflammation in asthma.
Journal ArticleDOI
IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.
Sergei V. Kotenko,Grant Gallagher,Vitaliy V. Baurin,Anita Lewis-Antes,Meiling Shen,Nital K. Shah,Jerome A. Langer,Faruk Sheikh,Harold Dickensheets,Raymond P. Donnelly +9 more
TL;DR: The identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state and may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs.
Journal ArticleDOI
Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group
Romain Pauwels,Claes-Göran Löfdahl,Dirkje S. Postma,Anne E. Tattersfield,Paul M. O'Byrne,Peter J. Barnes,A Ullman +6 more
TL;DR: In patients who have persistent symptoms of asthma despite treatment with inhaled glucocorticoids, the addition of formoterol to budesonid therapy or the use of a higher dose of budesonide may be beneficial.
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