Impaired innate interferon induction in severe therapy resistant atopic asthmatic children.
Michael R. Edwards,Nicolas Regamey,Marjolaine Vareille,Elisabeth Kieninger,Atul Gupta,Amelia Shoemark,Sejal Saglani,A Sykes,J Macintyre,Jane C. Davies,C Bossley,Andrew Bush,Sebastian L. Johnston +12 more
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TLDR
It is shown that compared with non-allergic healthy control children, bronchial epithelial cells cultured ex vivo from severe therapy resistant atopic asthmatic children have profoundly impaired interferon-β and interferons-λ mRNA and protein in response to rhinovirus (RV) and polyIC stimulation, and this is a feature of STRA.About:
This article is published in Mucosal Immunology.The article was published on 2013-07-01 and is currently open access. It has received 189 citations till now. The article focuses on the topics: Interferon.read more
Citations
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TLR7/8 regulates type I and type III interferon signalling in rhinovirus 1b-induced allergic asthma.
Jasmin Krug,Alexander Kiefer,Julia Koelle,Tytti Vuorinen,Paraskevi Xepapadaki,Barbara Stanic,Mircea T. Chiriac,Mübeccel Akdis,Theodor Zimmermann,Nikolaos G. Papadopoulos,Nikolaos G. Papadopoulos,Susetta Finotto +11 more
TL;DR: In PBMCs from pre-school age children, IFN-αR mRNA was reduced and IFn-λR1 mRNA was induced upon treatment with the TLR7/8 agonist R848, thus suggesting new avenues for induction of antiviral immune responses in paediatric asthma.
Journal ArticleDOI
Impaired airway epithelial cell wound‐healing capacity is associated with airway remodelling following RSV infection in severe preschool wheeze
Cecilia Andersson,Jua Iwasaki,James Cook,Polly F. M. Robinson,Prasad Nagakumar,Sofia Mogren,Louise Fleming,Andrew Bush,Sejal Saglani,Clare M. Lloyd +9 more
TL;DR: The anti‐viral and repair responses of the bronchial epithelium in children with severe therapy‐resistant asthma (STRA) and PSW are poorly understood.
Journal ArticleDOI
Pseudomonas aeruginosa Modulates the Antiviral Response of Bronchial Epithelial Cells.
Michael Sörensen,Julia Kantorek,Lauren Byrnes,Sébastien Boutin,Marcus A. Mall,Felix Lasitschka,H Zabeck,Dao Nguyen,Alexander H. Dalpke,Alexander H. Dalpke +9 more
TL;DR: It is shown that P. aeruginosa is able to block the antiviral response of airway epithelial cells thereby promoting virus infection and spread, and the infection status of CF patients correlated significantly with the amount of respiratory viruses in sputum.
Journal ArticleDOI
Experimental Antiviral Therapeutic Studies for Human Rhinovirus Infections.
TL;DR: A review of the up-to-date virological and immunological understanding of rhinovirus infection can be found in this article, where the authors discuss the challenges researchers face, and key solutions, in their work to investigate potential therapies including in vivo RHINovirus challenge studies.
Journal ArticleDOI
Anti-viral agents: potential utility in exacerbations of asthma.
TL;DR: The role of respiratory viral infection in asthma exacerbation is discussed and current and potential anti-viral agents and their mechanisms of action are highlighted.
References
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A diverse range of gene products are effectors of the type I interferon antiviral response
John W. Schoggins,Sam J. Wilson,Maryline Panis,Mary Murphy,Christopher T. Jones,Paul D. Bieniasz,Charles M. Rice +6 more
TL;DR: It is shown that different viruses are targeted by unique sets of ISGs, and that each viral species is susceptible to multiple antiviral genes, which together encompass a range of inhibitory activities.
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Community study of role of viral infections in exacerbations of asthma in 9-11 year old children.
Sebastian L. Johnston,Philip Pattemore,G. Sanderson,Sandra Smith,F Lampe,Lynn Josephs,P. Symington,S. O'Toole,S. H. Myint,D. A. J. Tyrrell +9 more
TL;DR: This study supports the hypothesis that upper respiratory viral infections are associated with 80-85% of asthma exacerbations in school age children.
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A large-scale, consortium-based genomewide association study of asthma.
Miriam F. Moffatt,Ivo Gut,Florence Demenais,David P. Strachan,Emmanuelle Bouzigon,Simon Heath,Erika von Mutius,Martin Farrall,Mark Lathrop,William O.C.M. Cookson +9 more
TL;DR: A few common alleles are associated with disease risk at all ages and suggest a role for communication of epithelial damage to the adaptive immune system and activation of airway inflammation in asthma.
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IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.
Sergei V. Kotenko,Grant Gallagher,Vitaliy V. Baurin,Anita Lewis-Antes,Meiling Shen,Nital K. Shah,Jerome A. Langer,Faruk Sheikh,Harold Dickensheets,Raymond P. Donnelly +9 more
TL;DR: The identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state and may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs.
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Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group
Romain Pauwels,Claes-Göran Löfdahl,Dirkje S. Postma,Anne E. Tattersfield,Paul M. O'Byrne,Peter J. Barnes,A Ullman +6 more
TL;DR: In patients who have persistent symptoms of asthma despite treatment with inhaled glucocorticoids, the addition of formoterol to budesonid therapy or the use of a higher dose of budesonide may be beneficial.
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