Impaired innate interferon induction in severe therapy resistant atopic asthmatic children.
Citations
10 citations
Cites background from "Impaired innate interferon inductio..."
...This impaired interferon production has subsequently been demonstrated in severe, therapy-resistant atopic asthma in children [69], but not in well-controlled asthma [70]....
[...]
10 citations
Cites background from "Impaired innate interferon inductio..."
...It has been reported that HAE from asthmatic subjects have impaired production of both Type I and Type III IFNs [67,68], with subsequent studies indicating that IFN deficiency was not seen in well-controlled asthma [66], but was seen in severe, therapy-resistant asthmatic children [69]....
[...]
9 citations
Cites background from "Impaired innate interferon inductio..."
...tially important protective role for type I IFN signaling in asthma exacerbations [101,102]....
[...]
9 citations
9 citations
References
1,926 citations
1,889 citations
1,764 citations
"Impaired innate interferon inductio..." refers background in this paper
...Array studies(22) have not found that these pattern recognition receptors are poorly expressed in asthma, and large genotyping studies have not highlighted any single-nucleotide polymorphisms associated with asthma for these genes.(41,42) These receptors also activate signaling pathways that are also common for pro-inflammatory cytokines,(18) which are not consistently reduced in studies where impaired IFN are observed....
[...]
1,725 citations
1,519 citations