Impaired Kynurenine Pathway Metabolism in The Prefrontal Cortex of Individuals With Schizophrenia
Citations
41 citations
Cites background from "Impaired Kynurenine Pathway Metabol..."
...It’s reported that the increased levels of the kynurenine (KYN) and kynurenic acid (KYNA) occurred in postmortem brain and cerebrospinal fluid of schizophrenia patients (Sathyasaikumar et al. 2011; Linderholm et al. 2012)....
[...]
40 citations
40 citations
40 citations
Cites background from "Impaired Kynurenine Pathway Metabol..."
...…transmission in schizophrenia, the concentration of kynurenic acid (KYNA) is elevated in the cerebrospinal fluid (CSF) and in post mortem brain of patients with schizophrenia (Erhardt et al., 2001a; Linderholm et al., 2012; Nilsson et al., 2005; Sathyasaikumar et al., 2011; Schwarcz et al., 2001)....
[...]
40 citations
Cites background from "Impaired Kynurenine Pathway Metabol..."
...In addition, in the prefrontal cortex of individuals with schizophrenia, it was demonstrated that there was a decrease in the levels of KMO activity (Sathyasaikumar et al., 2011)....
[...]
References
289,852 citations
2,429 citations
"Impaired Kynurenine Pathway Metabol..." refers result in this paper
...The activity of 3-HAO, which catalyzes the formation of the NMDA receptor agonist quinolinic acid from 3hydroxyanthranilic acid, was found to be reduced in BA 9, ie, the dorsolateral subdivision of the PFC that is preferentially involved in sustaining attention and working memory.(48) A tendency toward lower 3-HAO activity was also observed in BA 10, though the results were not statistically significant....
[...]
886 citations
764 citations
623 citations
"Impaired Kynurenine Pathway Metabol..." refers background in this paper
...linked to cognitive phenomena and psychosis, ie, the a7 nicotinic acetylcholine receptor (a7nAChR)(12) and the N-methyl-D-aspartate (NMDA) receptor.(13) By reducing...
[...]