Impaired Kynurenine Pathway Metabolism in The Prefrontal Cortex of Individuals With Schizophrenia
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Cites background from "Impaired Kynurenine Pathway Metabol..."
...Elevated concentrations of KYNA have been found in the cerebrospinal fluid (CSF) (Nilsson et al., 2005) and in the postmortem prefrontal cortex (Sathyasaikumar et al., 2011) of patients with schizophrenia....
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..., 2005) and in the postmortem prefrontal cortex (Sathyasaikumar et al., 2011) of patients with schizophrenia....
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"Impaired Kynurenine Pathway Metabol..." refers result in this paper
...The activity of 3-HAO, which catalyzes the formation of the NMDA receptor agonist quinolinic acid from 3hydroxyanthranilic acid, was found to be reduced in BA 9, ie, the dorsolateral subdivision of the PFC that is preferentially involved in sustaining attention and working memory.(48) A tendency toward lower 3-HAO activity was also observed in BA 10, though the results were not statistically significant....
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"Impaired Kynurenine Pathway Metabol..." refers background in this paper
...linked to cognitive phenomena and psychosis, ie, the a7 nicotinic acetylcholine receptor (a7nAChR)(12) and the N-methyl-D-aspartate (NMDA) receptor.(13) By reducing...
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