Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
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Cites background from "Impaired Nociception and Pain Sensa..."
...Lack of such sensitization in TRPV1-deficient mice provides genetic support for the idea that TRPV1 is a key component of the mechanism through which inflammation produces thermal hyperalgesia (Caterina et al., 2000; Davis et al., 2000)....
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...These studies also demonstrated an essential role for this channel in the process whereby tissue injury and inflammation leads to heat hypersensitivity, reflecting the ability of TRPV1 to serve as a molecular integrator of thermal and chemical stimuli (Caterina et al., 2000; Davis et al., 2000)....
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...Fourth, analysis of mice lacking this ion channel not only revealed a complete loss of capsaicin sensitivity, but these animals also exhibited significant impairment in their ability to detect and respond to noxious heat (Caterina et al., 2000; Davis et al., 2000)....
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2,565 citations
Cites background from "Impaired Nociception and Pain Sensa..."
...Accordingly, stimulation of VR1 receptors on the central and peripheral terminals of C fibres may contribute to its influence upon nociception (Caterina et al., 2000; Di Marzo et al., 2000; De Petrocellis et al., 2001; Gauldie et al., 2001; Morisset et al., 2001; Tognetto et al., 2001)....
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References
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