Implications of the virus-encoded miRNA and host miRNA in the pathogenicity of SARS-CoV-2
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...[114] used computational methods to investigate the SARSCoV-2 genome for alleged miRNAs and detected the viral miRNA targets on the virus, and human genome simultaneously and also detected the human miRNAs that can target the viral genome....
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...Besides, they examined miRNAs implicated in dysregulation prompted by a viral disease that involved the immunity and cytoskeleton structure, which are the common critical biological means modulated by the miRNAs, induced by infection [114]....
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...3p and miRNA 359-5p that target and enhance the activity of Adenosine Deaminases Acting on RNA (ADAR) and non-muscle myosin heavy chain 9 (MYH9), respectively [64]....
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...CHAC1 and RAD9A are two crucial proteins for apoptosis [63] and found to be targeted by two SARS-CoV-2 viral miRNAs, namely as, miRNA MD2-5p and miRNA 147-3p [64]....
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...miRNA 66-3p was identified to target the transcription enhancer of TNF-α, a very well-known cytokine [64]....
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44 citations
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...Furthermore, another computational study found that virus miRNA has greater regulation of the biological process of the immune response and the cytoskeleton, which could create a greater effect on the viral life cycle [36]....
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"Implications of the virus-encoded m..." refers background in this paper
...e were miRNA 2 targets at the 5′ UTR of the virus genome, and at the 2 S gene, which encodes a spike glycoprotein to bind its receptor ACE2 on human cells, and mediates membrane fusion and virus entry(5). Twenty-eight human miRNAs were predicted to have 30 targets on the SASRS-CoV-2 genome (Figure 5B). Most of the human miRNAs were bind to the , where the enzymes for virus replication ORF1ab and tran...
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9,231 citations