Improve Glioblastoma Multiforme Prognosis Prediction by Using Feature Selection and Multiple Kernel Learning
Citations
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333 citations
Cites methods from "Improve Glioblastoma Multiforme Pro..."
...SimpleMKL-based [74] multiple kernel learning has been applied in [75] to predict cancer prognosis by using gene expres-...
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304 citations
185 citations
Cites background or methods from "Improve Glioblastoma Multiforme Pro..."
...For improving drug sensitivity in breast cancer, genomics, epigenomics, and proteomics, data were integrated using a multiview multiple kernel learning (MKL) approach [25]....
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...For example, Glioblastoma Multiforme is a highly aggressive type of brain cancer whose prognostic prediction can be improved by considering multiple data types together [77], i....
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...Moreover, scalable MKL methods like dual-layer kernel extreme learning machine (DKELM) [198] and easyMKL [199] can be employed in multi-omics integrative analysis since MKL, a popular approach for integrating multiple omics datasets, can be computationally very expensive for large datasets....
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...Multiple kernel learning (MKL) [82] has become a popular approach to integrate data by calculating individual kernel matrices for each data type and fusing them into a global model....
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...For example, a feed-forward neural network with multiple hidden layers can now be trained to accurately differentiate non-coding RNA types, i.e., circular RNAs (cirRNAs) from long non-coding RNAs (lncRNAs) in just a few hours on a single computer while the MKL method would take four days [182]....
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174 citations
Cites background or methods from "Improve Glioblastoma Multiforme Pro..."
...propose a multiple kernel machine learning method by fusing different types of data for the GBM prognosis prediction [16]....
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...To further demonstrate the predictive results of the multi-dimensional data in assessing the risk of developing distant metastases in breast cancer patients, survival data analyses of the proposed method is also performed according to previous studies [16], [51], [52], the Kaplan-Meier curve is plotted and shown in Fig....
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...The optimal parameters are chosen by the parameter combination leading to the best performance (AUC value) [16], [44]....
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...mRMR [36] is one of the most common dimensionality reduction algorithm in a wide range of applications [16], [37], [38]....
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...To comprehensively evaluate our proposed method, we use ten-fold cross validation experiment in consistent with previous existing studies of cancer prognosis prediction [16], [48]....
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References
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"Improve Glioblastoma Multiforme Pro..." refers background in this paper
...Recent development in gene testing has evolved classic subtype rules to more specific classification rules based on single biomolecular features....
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13,134 citations
"Improve Glioblastoma Multiforme Pro..." refers background in this paper
...However, the real power behind the massive data is still under covered....
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