Improved two-dimensional J-resolved spectroscopy.

doi:10.1002/NBM.1027

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Improved two-dimensional J-resolved spectroscopy.

Journal Article•DOI•

Improved two-dimensional J-resolved spectroscopy.

Rolf F. Schulte¹, Thomas Lange¹, Johannes Beck², Dieter Meier¹, Peter Boesiger¹ - Show less +1 more•Institutions (2)

ETH Zurich¹, University of Zurich²

01 Apr 2006-NMR in Biomedicine (John Wiley & Sons, Ltd.)-Vol. 19, Iss: 2, pp 264-270

TL;DR: The qualitative behaviour of eddy currents in JPRESS is outlined and a 2D eddy current correction procedure based on the 1D phase deconvolution method is proposed.

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Abstract: Localised two-dimensional J-resolved spectroscopy (JPRESS) is optimised for the in vivo detection of J-coupled metabolites using magnetic resonance spectroscopy at 3 T. The acquisition of echo signals starts as early as possible (i.e. maximum-echo sampling). This sampling scheme increases sensitivity and decreases overlap of peak tails, hence alleviating baseline problems. Reconstruction issues are discussed and the sensitivity is compared analytically with that of 1D PRESS. The qualitative behaviour of eddy currents in JPRESS is outlined and a 2D eddy current correction procedure based on the 1D phase deconvolution method is proposed.

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Journal Article•DOI•

In vivo magnetic resonance spectroscopy of GABA: a methodological review.

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Nicolaas A.J. Puts¹, Richard A.E. Edden²•Institutions (2)

Cardiff University¹, Johns Hopkins University School of Medicine²

01 Jan 2012-Progress in Nuclear Magnetic Resonance Spectroscopy

TL;DR: The purpose of this review is to introduce MRS methods that detect GABA in vivo, and to summarize the existing published literature applying these methods.

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321 citations

Cites methods from "Improved two-dimensional J-resolved..."

...have implemented a two-dimensional fitting algorithm for 2D J-resolved spectra [14,25], Jensen et al....
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...[25] 2DJ 3 16 17 ParGM 27...
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Journal Article•DOI•

The relationship between aberrant neuronal activation in the pregenual anterior cingulate, altered glutamatergic metabolism, and anhedonia in major depression.

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Martin Walter¹, Anke Henning², Simone Grimm³, Rolf F. Schulte⁴, Johannes Beck⁵, Ulrike Dydak⁶, Betina Schnepf³, Heinz Boeker³, Peter Boesiger³, Georg Northoff - Show less +6 more•Institutions (6)

Otto-von-Guericke University Magdeburg¹, ETH Zurich², University of Zurich³, General Electric⁴, University of Basel⁵, Indiana University⁶

01 May 2009-Archives of General Psychiatry

TL;DR: Aberrant neuronal activation patterns of the pgACC in anhedonic depression are related to deficits of glutamatergic metabolism, a cortical region linked to anhedonia.

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Abstract: Context: Major depressive disorder (MDD) is characterized by diverse metabolic and functional abnormalities that occur in, among other regions, the pregenual anterior cingulate cortex (pgACC), a cortical region linked to anhedonia. Objectives: To contextualize metabolic, functional, and clinical parameters and thus to reveal cellular mechanisms related to anhedonia. Design: The pgACC was investigated using a combined functional magnetic resonance imaging and magnetic resonance spectroscopic approach. Negative blood oxygenation level–dependent (BOLD) activations in the pgACC were assessed during emotional stimulation. Quantitative J-resolved magnetic resonance spectroscopy in the pgACC enabled simultaneous determination of glutamine, glutamate,N-acetylaspartate, glucose, and-aminobutyric acid concentrations. Subjective emotional intensity ratings as well as various clinical parameters were determined. Setting: The patients were recruited and evaluated in the Department of Psychiatry, University of Zurich, while the measurements were performed in the Institute of Biomedical Engineering, University of Zurich and the Technical University Zurich. Participants: Nineteen unmedicated patients with MDD and 24 healthy subjects. Main Outcome Measures: Reduced glutamine levels and lower functional responses in pgACC in anhedonic depressed patients were expected to be the predominant effect of abnormal glutamatergic transmission. It was further tested if, among patients, the ratings of emotional intensity on visual stimulation predicted the amount of metabolic and functional alterations in terms of reduced relative metabolite concentrations and BOLD changes. Results: Patients with highly anhedonic MDD show decreased glutamine but normal glutamate and -aminobutyric acid concentrations, with glutamine concentrations being dissociated from glucose concentrations. Glutamate andN-acetylaspartate concentrations in pgACC correlate with negative BOLD responses induced by emotional stimulation in MDD; whereas in healthy subjects, negative BOLD responses correlate with -aminobutyric acid instead. Negative BOLD responses as well as glutamate and N-acetylaspartate concentrations correlate with emotional intensity ratings, an anhedonia surrogate, in those with MDD but not in healthy subjects.

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285 citations

Cites result from "Improved two-dimensional J-resolved..."

...In contrast to previous studies,(20-22) the use of 2-dimensional J-resolved MRS allowed for separate quantification of Glu and Gln along with simultaneous assessment of GABA, Glc, and NAA concentrations.(25,26) This metabolic dimension had to be aligned with the assessment of functional responses on emotional stimuli using fMRI....
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Journal Article•DOI•

Posteromedial cortex glutamate and GABA predict intrinsic functional connectivity of the default mode network

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Dimitrios Kapogiannis¹, David A. Reiter¹, Auriel A. Willette¹, Mark P. Mattson¹•Institutions (1)

National Institutes of Health¹

01 Jan 2013-NeuroImage

TL;DR: It is concluded that regional neurotransmitter concentrations in a network node strongly predict network but not global brain iFC.

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176 citations

Cites methods from "Improved two-dimensional J-resolved..."

...Relative metabolite concentrations were determined using the Prior-Knowledge Fitting procedure (ProFit), which fits linear combinations of simulated two-dimensional basis metabolite spectra (Schulte and Boesiger, 2006; Schulte et al., 2006); metabolite amounts are reported as their ratio to creatine....
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...To obtain unambiguous quantification of GABA and glutamate simultaneously, we acquired two-dimensional J-resolved spectra (Schulte et al., 2006), which permit better separation of overlapping metabolites by spreading them in an additional dimension sensitive to jmodulations (Fig....
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...…metabolite concentrations were determined using the Prior-Knowledge Fitting procedure (ProFit), which fits linear combinations of simulated two-dimensional basis metabolite spectra (Schulte and Boesiger, 2006; Schulte et al., 2006); metabolite amounts are reported as their ratio to creatine....
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..., 1984, 1993) – we acquired a two-dimensional j-resolved spectrum using a JPRESS sequence with maximum-echo sampling (Aue et al., 1976; Schulte et al., 2006)....
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...…resonance substantially overlaps with several other metabolites in a standard one-dimensional spectrum (Behar and Ogino, 1991; Rothman et al., 1984, 1993) – we acquired a two-dimensional j-resolved spectrum using a JPRESS sequence with maximum-echo sampling (Aue et al., 1976; Schulte et al., 2006)....
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Journal Article•DOI•

Rapid Enhancement of Glutamatergic Neurotransmission in Bipolar Depression Following Treatment with Riluzole

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Brian P. Brennan¹, Brian P. Brennan², James I. Hudson², James I. Hudson¹, J. Eric Jensen², J. Eric Jensen¹, Julie M. McCarthy¹, Jacqueline L. Roberts¹, Andrew P. Prescot³, Bruce M. Cohen¹, Bruce M. Cohen², Harrison G. Pope², Harrison G. Pope¹, Perry F. Renshaw³, Dost Öngür², Dost Öngür¹ - Show less +12 more•Institutions (3)

McLean Hospital¹, Harvard University², University of Utah³

01 Feb 2010-Neuropsychopharmacology

TL;DR: Riluzole seems to rapidly increase Gln/Glu ratios—suggesting increased glutamate–glutamine cycling, which may subsequently enhance neuronal plasticity and reduce depressive symptoms.

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154 citations

Cites background from "Improved two-dimensional J-resolved..."

...…by using all available signals rather than by fitting select single J-resolved extractions (Jensen et al, 2009; Schulte and Boesiger, 2006a; Schulte et al, 2006b), and has been shown to greatly improve the accuracy and precision of separate measurements of the coupled and highly overlapped…...
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...As a result, the advantages of J-resolved 1HMRS (its ability to collect additional data on difficult-toquantify metabolites (Schulte et al, 2006b) and metabolite T2 relaxation times) and its disadvantages (longer scan times and potential drift in data quality during the scan) must be weighed when…...
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Journal Article•DOI•

Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate

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Ovidiu C. Andronesi¹, Otto Rapalino, Elizabeth R. Gerstner, Andrew S. Chi, Tracy T. Batchelor, Daniel P. Cahill, A. Gregory Sorensen, Bruce R. Rosen - Show less +4 more•Institutions (1)

Harvard University¹

03 Sep 2013-Journal of Clinical Investigation

TL;DR: Recent efforts to translate methodology using MRS to reliably measure in vivo D-2HG into clinical research are reviewed.

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Abstract: The investigation of metabolic pathways disturbed in isocitrate dehydrogenase (IDH) mutant tumors revealed that the hallmark metabolic alteration is the production of D-2-hydroxyglutarate (D-2HG). The biological impact of D-2HG strongly suggests that high levels of this metabolite may play a central role in propagating downstream the effects of mutant IDH, leading to malignant transformation of cells. Hence, D-2HG may be an ideal biomarker for both diagnosing and monitoring treatment response targeting IDH mutations. Magnetic resonance spectroscopy (MRS) is well suited to the task of noninvasive D-2HG detection, and there has been much interest in developing such methods. Here, we review recent efforts to translate methodology using MRS to reliably measure in vivo D-2HG into clinical research.

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145 citations

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References

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Book•

Principles of nuclear magnetic resonance in one and two dimensions

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Richard R. Ernst, Geoffrey Bodenhausen, Alexander Wokaun, Alfred G. Redfield

01 Jan 1987

TL;DR: In this paper, the dynamics of nuclear spin systems were studied by two-dimensional exchange spectroscopy and nuclear magnetic resonance imaging (NEMI) imaging, and two different correlation methods based on coherence transfer were proposed.

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Abstract: List of notation Introduction The dynamics of nuclear spin systems Manipulation of nuclear spin Hamiltonians One-dimensional Fourier spectroscopy Multiple-quantum transitions Two-dimensional Fourier spectroscopy Two-dimensional separation of interactions Two-dimensional correlation methods based on coherence transfer Dynamic processes studied by two-dimensional exchange spectroscopy Nuclear magnetic resonance imaging References Index.

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4,977 citations

Journal Article•DOI•

Two‐dimensional spectroscopy. Application to nuclear magnetic resonance

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W. P. Aue, E. Bartholdi, Richard R. Ernst

01 Mar 1976-Journal of Chemical Physics

TL;DR: In this article, the possibilities for the extension of spectroscopy to two dimensions are discussed, including the elucidation of energy level diagrams, the observation of multiple quantum transitions, and the recording of high-resolution spectra in inhomogenous magnetic fields.

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Abstract: The possibilities for the extension of spectroscopy to two dimensions are discussed. Applications to nuclear magnetic resonance are described. The basic theory of two‐dimensional spectroscopy is developed. Numerous possible applications are mentioned and some of them treated in detail, including the elucidation of energy level diagrams, the observation of multiple quantum transitions, and the recording of high‐resolution spectra in inhomogenous magnetic fields. Experimental results are presented for some simple spin systems.

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2,968 citations

Journal Article•DOI•

Elucidation of cross relaxation in liquids by two-dimensional N.M.R. spectroscopy

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Macura Slobodan, Richard R. Ernst¹•Institutions (1)

ETH Zurich¹

01 Sep 1980-Molecular Physics

TL;DR: In this article, the influence of the correlation time of the molecular random process is investigated and it is found that in the limit of short correlation times (extreme narrowing limit) weak negative cross peaks are observed.

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Abstract: Two-dimensional N.M.R. spectroscopy is applied to the elucidation of cross relaxation pathways in liquids. The theory underlying two dimensional studies of cross relaxation and of transient nuclear Overhauser effects is developed. The influence of the correlation time of the molecular random process is investigated. It is found that in the limit of short correlation times (extreme narrowing limit) weak negative cross-peaks are observed. However, for long correlation times (spin diffusion limit) strong positive cross-peaks can be obtained. The technique appears particularly promising for the study of cross relaxation in macromolecules. Examples of intra- and intermolecular cross relaxation in the extreme narrowing limit are presented.

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1,452 citations

Journal Article•DOI•

Spatial localization in NMR spectroscopy in vivo.

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Paul A. Bottomley¹•Institutions (1)

General Electric¹

01 Nov 1987-Annals of the New York Academy of Sciences

TL;DR: DRESS is a simple and versatile localization procedure that is readily adaptable to spectral relaxation time measurements by adding inversion or spin-echo refocusing pulses or to in vivo solvent-suppressed spectroscopy of proton (1H) metabolites using a combination of chemical-selective RF pulses.

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Abstract: Spatial localization techniques are necessary for in vivo NMR spectroscopy involving heterogeneous organisms. Localization by surface coil NMR detection alone is generally inadequate for deep-lying organs due to contaminating signals from intervening surface tissues. However, localization to preselected planar volumes can be accomplished using a single selective excitation pulse in the presence of a pulsed magnetic field gradient, yielding depth-resolved surface coil spectra (DRESS). Within selected planes, DRESS are spatially restricted by the surface coil sensitivity profiles to disk-shaped volumes whose radii increase with depth, notwithstanding variations in the NMR signal density distribution. Nevertheless, DRESS is a simple and versatile localization procedure that is readily adaptable to spectral relaxation time measurements by adding inversion or spin-echo refocusing pulses or to in vivo solvent-suppressed spectroscopy of proton (1H) metabolites using a combination of chemical-selective RF pulses. Also, the spatial information gathering efficiency of the technique can be improved to provide simultaneous acquisition of spectra from multiple volumes by interleaving excitation of adjacent planes within the normal relaxation recovery period. The spatial selectivity can be improved by adding additional selective excitation spin-echo refocusing pulses to achieve full, three-dimensional point resolved spectroscopy (PRESS) in a single excitation sequence. Alternatively, for samples with short spin-spin relaxation times, DRESS can be combined with other localization schemes, such as image-selected in vivo spectroscopy (ISIS), to provide complete gradient controlled three-dimensional localization with a reduced number of sequence cycles.

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1,391 citations

Journal Article•DOI•

Homonuclear broad band decoupling and two-dimensional J-resolved NMR spectroscopy

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