In silico functional annotation of a hypothetical protein from Staphylococcus aureus.
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TLDR
The investigation and characterization of the likely functional aspects of a hypothetical protein, YP_001317347.1, from Staphylococcus aureus was performed using various computational methods and tools and helps in understanding the importance of YbbR domains and will aid in the development of novel antibacterial agents.About:
This article is published in Journal of Infection and Public Health.The article was published on 2015-11-01 and is currently open access. It has received 34 citations till now. The article focuses on the topics: Hypothetical protein.read more
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Functional annotation of hypothetical proteins from the Exiguobacterium antarcticum strain B7 reveals proteins involved in adaptation to extreme environments, including high arsenic resistance.
Wana Lailan Oliveira da Costa,Carlos Leonardo Araújo,Larissa M. Dias,Lino César Pereira,Jorianne Thyeska Castro Alves,Fabricio Araujo,Edson Luiz Folador,Isabel Henriques,Artur Silva,Adriana Ribeiro Carneiro Folador +9 more
TL;DR: This study aimed to assign functions to proteins previously described as HPs, present in the genome of E. antarcticum B7, to produce a better understanding of the mechanism by which this bacterium adapts to extreme environments and to the finding of targets with biotechnological interest.
Journal ArticleDOI
High-throughput proteomics and metabolomic studies guide re-engineering of metabolic pathways in eukaryotic microalgae: A review
Hillol Chakdar,Mafruha T. Hasan,Sunil Pabbi,Helena Nevalainen,Pratyoosh Shukla,Pratyoosh Shukla +5 more
TL;DR: The present review highlights the application of contemporary proteomic and metabolomic techniques in eukaryotic microalgae for redesigning pathways for enhanced production of algal metabolites.
Journal ArticleDOI
An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c-di-AMP in Listeria monocytogenes.
Johannes Gibhardt,Jana L. Heidemann,Rica Bremenkamp,Jonathan Rosenberg,Roland Seifert,Volkhard Kaever,Ralf Ficner,Fabian M. Commichau +7 more
TL;DR: It is demonstrated that the extracytoplasmic regulator CdaR interacts with CdaA via its transmembrane helix to modulate c-di-AMP production and that the phosphoglucosamine mutase GlmM forms a complex with C daA and inhibits the diadenylate cyclase activity in vitro.
Journal ArticleDOI
Prediction driven functional annotation of hypothetical proteins in the major facilitator superfamily of S. aureus NCTC 8325.
TL;DR: These findings provide better annotation for the existing genome, and identify proteins related to antibiotic resistance in S. aureus NCTC 8325 by identifying hypothetical protein homologs related to the Major Facilitator Superfamily.
Journal ArticleDOI
Spindlin docking protein (SPIN.DOC) interaction with SPIN1 (a histone code reader) regulates Wnt signaling.
Mairembam Saroj Devi,Remmei Meiguilungpou,Adhikarimayum Lakhikumar Sharma,Chirom Anjali,Khuraijam Mrinalini Devi,Lisam Shanjukumar Singh,Thiyam Ramsing Singh +6 more
TL;DR: It is revealed that the suppression of SPIN.DOC expression in HEK293 cells by shRNA, slightly destabilized SPIN1 without any change in its chromatin localization, and it is shown that C-terminal deleted mutant of SPin.DOC is unable to interact with SPin1, suggesting that SPIN-SPIN1 complex may act as transcriptional repressor.
References
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