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Journal ArticleDOI

In Silico Identification and Analysis of Drug Resistant Mutants of ABL Tyrosine Kinase Based on Detrimental Missense Mutations

R. Rajasekaran, +3 more
- 31 Aug 2011 - 
- Vol. 6, Iss: 3, pp 396-404
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This article is published in Current Signal Transduction Therapy.The article was published on 2011-08-31. It has received 3 citations till now. The article focuses on the topics: In silico.

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Journal ArticleDOI

Extrapolating the effect of deleterious nsSNPs in the binding adaptability of flavopiridol with CDK7 protein: a molecular dynamics approach.

C. George Priya Doss, +6 more
- 05 Apr 2013 - 
TL;DR: A theoretical assessment for the discovery of new drugs or drug targets in CDK7 protein owing to the changes caused by deleterious nsSNPs is described and the identification of disease related SNPs by computational methods has the potential to create personalized tools for the diagnosis, prognosis, and treatment of diseases.
Journal ArticleDOI

Identification and structural characterization of deleterious non-synonymous single nucleotide polymorphisms in the human SKP2 gene

S. M. Zahid Hosen, +5 more
- 01 Apr 2019 - 
TL;DR: The study revealed that P101L and Y346C mutations increased the flexibility and changed the structural dynamics of SKP2 protein, which might be helpful to consider these nsSNPs for wet-lab confirmatory analysis as well as in rationalizing future population based studies and structure based drug design againstSKP2.
Journal ArticleDOI

Predicting the Impact of Single-Nucleotide Polymorphisms in CDK2–Flavopiridol Complex by Molecular Dynamics Analysis

N. Nagasundaram, +1 more
- 09 Jan 2013 - 
TL;DR: Analysis of 10-ns molecular dynamics simulation trajectories indicated that the predicted deleterious variants of CDK2 altered theCDK2 stability, flexibility, and surface area and noticed the decrease in number of hydrogen bonds between CDK1 and flavopiridol mutant complexes in the whole dynamic period.
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