Journal ArticleDOI
In silico toxicity as a tool for harm reduction: A study of new psychoactive amphetamines and cathinones in the context of criminal science.
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TLDR
Computer-calculated toxicity values of various amphetamines and cathinones are submitted to an unsupervised multivariate analysis, namely Principal Component Analysis (PCA), and to the supervised techniques Soft Independent Modeling of Class Analogy and Partial Least Square-Discriminant Analysis to evaluate how these two NPS groups behave.About:
This article is published in Science & Justice.The article was published on 2019-05-01. It has received 3 citations till now. The article focuses on the topics: Poison control.read more
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Screening of Synthetic Cathinones by Potentiometric Sensor Array and Chemometrics
TL;DR: In this article , the analytical applicability of single ion-selective membranes (ISMs) and potentiometric sensor array to distinguish and detect cathinone derivatives was demonstrated.
References
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Journal ArticleDOI
The FRAME multicentre project on in vitro cytotoxicology.
TL;DR: An in vitro method for assessing the relative acute toxicities of chemicals was developed through the collaboration of four tissue culture laboratories and gave results with a high degree of interlaboratory reproducibility.
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Monoamine transporter and receptor interaction profiles of a new series of designer cathinones.
TL;DR: The pharmacology of a new series of cathinones, including methedrone, 4-methylethcathinone (4-MEC), 3-fluoromethcath inone (3-FMC), pentylone, ethcathInone, buphedrone
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Novel psychoactive substances (designer drugs): overview and pharmacology of modulators of monoamine signaling.
TL;DR: The relative serotonergic vs dopaminergic activity can be helpful to predict the desired psychotropic but also the toxic effects of novel substances as well as their potential for addiction.
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Monoamine transporter and receptor interaction profiles of novel psychoactive substances: Para-halogenated amphetamines and pyrovalerone cathinones
TL;DR: Para-substituted amphetamines exhibited enhanced direct and indirect serotonergic agonist properties and are likely associated with more MDMA-like effects and the pharmacological profile of the pyrovalerone cathinones predicts pronounced stimulant effects and high abuse liability.
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Next generation of novel psychoactive substances on the horizon - A complex problem to face.
TL;DR: This review presents updated information on the second generation of NPS, introduced as replacements of the already banned substances from this class, focusing on their pharmacological properties and metabolism, routes of administration, and effects in humans.