In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep.
Jolanda Kluin,Hanna Talacua,Anthal I.P.M. Smits,Maximilian Y. Emmert,Marieke Brugmans,Emanuela S. Fioretta,Petra E. Dijkman,Serge H. M. Söntjens,Renee Duijvelshoff,Sylvia Dekker,Marloes W J T Janssen-van den Broek,Valentina Lintas,Aryan Vink,Simon P. Hoerstrup,Simon P. Hoerstrup,Henk M. Janssen,Patricia Y. W. Dankers,Frank P. T. Baaijens,Carlijn V. C. Bouten +18 more
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TLDR
A fibrous valvular scaffold is designed, fabricated from a novel supramolecular elastomer, that enables endogenous cells to enter and produce matrix and offer new perspectives for endogenous heart valve replacement starting from a readily-available synthetic graft that is compatible with surgical and transcatheter implantation procedures.About:
This article is published in Biomaterials.The article was published on 2017-05-01 and is currently open access. It has received 209 citations till now. The article focuses on the topics: Heart valve & Pulmonary Valve Replacement.read more
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Biofabrication strategies for 3D in vitro models and regenerative medicine
Lorenzo Moroni,Jason A. Burdick,Christopher B. Highley,Sang Jin Lee,Yuya Morimoto,Shoji Takeuchi,James J. Yoo +6 more
TL;DR: This Review examines biofabrication strategies for the construction of functional tissue replacements and organ models, focusing on the development of biomaterials, such as supramolecular and photosensitive materials, that can be processed using bioFabrication techniques.
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From supramolecular polymers to multi-component biomaterials.
TL;DR: This review shows the translation of one-dimensional supramolecular polymers into multi-component functional biomaterials for regenerative medicine applications.
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Biomaterial-driven in situ cardiovascular tissue engineering : a multi-disciplinary perspective
TL;DR: The main current challenges for in situ cardiovascular regeneration are pinpointed and further address, namely the achievement of tissue homeostasis, the development of predictive models for long-term performances of the implanted grafts, and the necessity for stratification for successful clinical translation.
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Antimicrobial Peptides in Biomedical Device Manufacturing
TL;DR: Synthetic antimicrobial peptides (AMPs) can be integrated in the design and manufacturing of additively manufactured/3D-printed implants, owing to the physicochemical characteristics of the implant material and the versatile manufacturing technologies compatible with antimicrobials incorporation.
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Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep model
Maximilian Y. Emmert,Boris Schmitt,S Sandra Loerakker,Bart Sanders,Hendrik Spriestersbach,Emanuela S. Fioretta,Leon Bruder,Kerstin Brakmann,Sarah E. Motta,Valentina Lintas,Petra E. Dijkman,Laura Frese,Felix Berger,Frank P. T. Baaijens,Simon P. Hoerstrup +14 more
TL;DR: The hypothesis that integration of a computationally inspired heart valve design into TE methodologies could guide tissue remodeling toward long-term functionality in tissue-engineered heart valves (TEHVs) is tested and suggests the relevance of an integrated in silico, in vitro, and in vivo bioengineering approach as a basis for the safe and efficient clinical translation of TEHVs.
References
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Journal ArticleDOI
Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue
TL;DR: A modified form of the dim methylmethylene blue assay is described that has improved specificity for sulphated glycosaminoglycans, and it is shown that in conjunction with specific polysaccharidases, the dimethylmethyleneblue assay can be used to quantitate individual sulphated sugarcans.
Journal ArticleDOI
Outcomes 15 years after valve replacement with a mechanical versus a bioprosthetic valve: final report of the Veterans Affairs randomized trial.
Karl E. Hammermeister,Gulshan K. Sethi,William G. Henderson,Frederick L. Grover,Charles Oprian,Shahbudin H. Rahimtoola +5 more
TL;DR: At 15 years, patients undergoing AVR had a better survival with a mechanical valve than with a bioprosthetic valve, largely because primary valve failure was virtually absent with mechanical valve.
Journal ArticleDOI
Improved microfluorometric DNA determination in biological material using 33258 Hoechst
TL;DR: Compared to other commonly used procedures this innovative and versatile technique can be conveniently applied to DNA microdetermination for the high sensibility/reproducibility ratio and can also be used without the need of previous purification steps.
Journal ArticleDOI
Functional Living Trileaflet Heart Valves Grown In Vitro
Simon P. Hoerstrup,Ralf Sodian,Sabine Daebritz,Jun Wang,Emile A. Bacha,David P. Martin,Adrian M. Moran,Kristine J. Guleserian,Jason S. Sperling,Sunjay Kaushal,Joseph P. Vacanti,Frederick J. Schoen,John E. Mayer +12 more
TL;DR: In vitro generation of implantable complete living heart valves based on a biomimetic flow culture system that functioned up to 5 months and resembled normal heart valves in microstructure, mechanical properties, and extracellular matrix formation.
Journal ArticleDOI
Midterm clinical result of tissue-engineered vascular autografts seeded with autologous bone marrow cells.
Toshiharu Shinoka,Goki Matsumura,Narutoshi Hibino,Yuji Naito,Manabu Watanabe,Takeshi Konuma,Takahiko Sakamoto,Masayoshi Nagatsu,Hiromi Kurosawa +8 more
TL;DR: Biodegradable conduits or patches seeded with autologous bone marrow cells showed normal function and the tissue-engineering approach may provide an important alternative to the use of prosthetic materials in the field of pediatric cardiovascular surgery.
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