Journal ArticleDOI
In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties.
Tiziana Adage,Anne-Cécile Trillat,Anna Quattropani,Dominique Perrin,Laurent Cavarec,Jeffrey P. Shaw,Oxana Guerassimenko,Claudio Giachetti,Beatrice Greco,Ilya Chumakov,Serge Halazy,Arthur Roach,Paola Zaratin +12 more
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TLDR
The results suggest that AS057278 has the potential to anti-psychotic action toward both cognitive and positive symptoms of schizophrenia.About:
This article is published in European Neuropsychopharmacology.The article was published on 2008-03-01. It has received 126 citations till now. The article focuses on the topics: Phencyclidine & Agonist.read more
Citations
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Realistic expectations of prepulse inhibition in translational models for schizophrenia research
TL;DR: This review enumerates the realistic expectations for PPI in translational models for schizophrenia research, and provides cautionary notes for the future applications of this important research tool.
Journal ArticleDOI
Add-on Treatment of Benzoate for Schizophrenia: A Randomized, Double-blind, Placebo-Controlled Trial of d-Amino Acid Oxidase Inhibitor
Hsien-Yuan Lane,Ching-Hua Lin,Michael F. Green,Michael F. Green,Gerhard Hellemann,Chih-Chia Huang,Po-Wei Chen,Rene Tun,Yue-Cung Chang,Guochuan E. Tsai +9 more
TL;DR: Benzoate adjunctive therapy significantly improved a variety of symptom domains and neurocognition in patients with chronic schizophrenia and the preliminary results show promise for d-amino acid oxidase inhibition as a novel approach for new drug development for schizophrenia.
Journal ArticleDOI
Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model
Viviane Labrie,Ryutaro Fukumura,Anjali Rastogi,Laura J. Fick,Wei Wang,Paul C. Boutros,James L. Kennedy,Mawahib O. Semeralul,Frankie H. F. Lee,Glen B. Baker,Denise D. Belsham,Steven W. Barger,Yoichi Gondo,Albert H.C. Wong,John C. Roder +14 more
TL;DR: Analysis of SRR genetic variants in humans identified a robust association with schizophrenia and demonstrates that aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis.
Journal ArticleDOI
Astroglial CB1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory.
Laurie M. Robin,José F. Oliveira da Cruz,Valentin C Langlais,Mario Martin-Fernandez,Mathilde Metna-Laurent,Arnau Busquets-Garcia,Luigi Bellocchio,Edgar Soria-Gomez,Thomas Papouin,Marjorie Varilh,Mark W. Sherwood,Ilaria Belluomo,Georgina Balcells,Isabelle Matias,Barbara Bosier,Filippo Drago,Ann Van Eeckhaut,Ilse Julia Smolders,François Georges,Alfonso Araque,Aude Panatier,Stéphane H. R. Oliet,Giovanni Marsicano,Giovanni Marsicano +23 more
TL;DR: It is shown that astroglial CB1 receptors are key determinants of object recognition memory by determining the availability of D-serine at hippocampal synapses and elevating D-Serine levels fully rescued LTP and memory impairments of GFAP-CB1-KO mice.
Journal ArticleDOI
The neurobiology of D -amino acid oxidase and its involvement in schizophrenia
TL;DR: This review critically review the neurobiology of DAO, its involvement in schizophrenia, and the therapeutic value ofDAO inhibition and highlights issues that have a broader relevance beyond DAO itself.
References
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New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening
Philip Skehan,Ritsa Storeng,Dominic A. Scudiero,Anne Monks,James B. McMahon,David T. Vistica,Jonathan T. Warren,Heidi R. Bokesch,Susan Kenney,Michael R. Boyd +9 more
TL;DR: The SRB assay provides a sensitive measure of drug-induced cytotoxicity, is useful in quantitating clonogenicity, and is well suited to high-volume, automated drug screening.
Journal ArticleDOI
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.
John H. Krystal,Laurence P. Karper,John Seibyl,Glenna K. Freeman,Richard C. Delaney,J. Douglas Bremner,George R. Heninger,Malcolm B. Bowers,Dennis S. Charney +8 more
TL;DR: These data indicate that N-methyl-D-aspartate antagonists produce a broad range of symptoms, behaviors, and cognitive deficits that resemble aspects of endogenous psychoses, particularly schizophrenia and dissociative states.
Journal ArticleDOI
Psychosis as a state of aberrant salience: A framework linking biology, phenomenology, and pharmacology in schizophrenia.
TL;DR: A heuristic framework for linking the psychological and biological in psychosis is provided and it is proposed that a dysregulated, hyperdopaminergic state, at a "brain" level of description and analysis, leads to an aberrant assignment of salience to the elements of one's experience, at an "mind" level.
Journal ArticleDOI
Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies.
TL;DR: A review of the literature on prepulse inhibition (PPI) in humans can be found in this article, where a relatively weak sensory event (the prepulse) is presented 30-500 ms before a strong startle-inducing stimulus, and reduces the magnitude of the startle response.
Journal ArticleDOI
Sensorimotor Gating and Schizophrenia: Human and Animal Model Studies
David L. Braff,Mark A. Geyer +1 more
TL;DR: Human and animal model studies of sensorimotor gating allow investigators to comment on the spatial and temporal mapping of neurons, trait and state deficits, and vulnerability factors in the schizophrenic spectrum of disorders.
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