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Journal ArticleDOI

In vitro bactericidal activity of biosynthesized CuS nanoparticles against UTI-causing pathogens

04 Aug 2017-Inorganic and Nano-Metal Chemistry (Taylor & Francis)-Vol. 47, Iss: 9, pp 1290-1297
TL;DR: CuS-NPs were found to exhibit good bactericidal property against the UTI after completing successful clinical trials and the antibacterial activity of CuS nanoparticles was analyzed against urinary tract infection pathogens.
Abstract: Nanoparticles are playing a vital role in antimicrobials. The culture supernatant of Serratia nematodiphila is used for reduction of copper sulfate into copper sulfide nanoparticles (CuS-NPs). The present study includes characterization of CdS nanoparticles using UV–vis spectrophotometer, size and morphology by SEM and TEM, and compositional analysis by energy-dispersive X-ray analysis (EDX). The CuS nanoparticles are 9–20 nm in size, measured using EM imaging. The antibacterial activity of CuS nanoparticles was analyzed against urinary tract infection (UTI) pathogens such as Escherichia coli, Staphylococcus aureus, Proteus vulgaris, and Klebsiella pneumoniae. CuS-NPs were found to exhibit good bactericidal property against the UTI after completing successful clinical trials.
Citations
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Journal ArticleDOI
TL;DR: In this article, a quick and environmentally friendly approach has been developed for the synthesis of CuS nanocrystals of different shape with antibacterial activity, and the process is completed.
Abstract: In the present study, a quick and environmentally friendly approach has been developed for the synthesis of CuS nanocrystals of different shape with antibacterial activity The process is completed

37 citations

Journal ArticleDOI
TL;DR: It is shown that by controlling the corrosion resistance and the wettability of the superhydrophobic copper substrate, it becomes possible to sustain the bactericidal action of copper substrates for a long time, simultaneously avoiding the excessive corrosive degradation and release of copper ions in the environment.

32 citations

Journal ArticleDOI
TL;DR: In this paper, undoped and nickel (Ni)-doped copper sulfide nanostructures were synthesized using a hydrothermal method at 150°C for 15'h.
Abstract: In recent years, copper sulfide has attracted great interest in biological application, due to its biocompatibility and low toxicity. Undoped and nickel (Ni)-doped copper sulfide nanostructures were synthesized using a hydrothermal method at 150 °C for 15 h. XRD patterns show that all samples have confirmed the formation of a hexagonal phase. Absorbance spectra were measured by using a UV–vis spectrophotometer. The optical bandgap energy of CuS nanostructure decreased with increasing Ni doping concentration. Their optical bandgap energies were 3.2, 3.21, 2.9, and 2.9 eV for undoped and Ni-doped copper sulfide nanostructures with concentrations of 1, 3, and 5%, respectively. The antibacterial activity of CuS nanostructure against E. coli, P. aeruginosa, and S. aureus was evaluated by zone of inhibition. The test revealed that the minimum concentration of CuS nanostructure has a strong antibacterial activity against Gram-positive bacteria than for Gram-negative bacteria. Antitumor treatment was applied based on employing CuS nanostructures by exploiting their unique optical and morphological properties as therapeutic agents against rhabdomyosarcoma (RD) and murine fibroblast (L20B) cancer cell lines without using laser. The cytotoxicity effect was evaluated by MTT assay; the results demonstrated that CuS nanostructure with 1% Ni doping exhibits more toxicity effect than undoped and doped nanostructures, with 3 and 5% for all particle concentrations, where cytotoxicity reaches 34.3% at 0.125 mg/ml, being the most influential concentration, which could be a promising agent for cancer treatment.

19 citations

Journal ArticleDOI
TL;DR: There must be active research in phyto-based therapies of UTIs, such as Ayurvedic Biology, as the role of medicinal plant-based nanotechnology approaches has shown promising results.
Abstract: Urinary tract infections (UTIs) are considered to be the most common infections worldwide, having an incidence rate of 40-60% in women. Moreover, the prevalence of this disorder in adult women is 30 times more than in men. UTIs are usually found in many hospitals and clinical practice; as disorders, they are complicated and uncomplicated; in uncomplicated cases, there is no structural or functional abnormality in the urogenital tract. However, obstruction, retention of urine flow and use of catheters increase the complexity. There are several bacteria (e.g., E. coli, Klebsiella pneumoniae, Proteus vulgaris, etc.) successfully residing in the tract. The diagnosis must not only be accurate but rapid, so early detection is an important step in the control of UTIs caused by uropathogens. The treatment of UTIs includes appropriate antimicrobial therapy to control the infection and kill the causal microbes inside the body. A long-time usage of antibiotics has resulted in multidrug resistance causing an impediment in treatment. Thus, alternative, combinatorial medication approaches have given some hope. Available treatments considered Homeopathic, Ayurvedic, Unani, and other herbal-based drugs. There are new upcoming roles of nanoparticles in combating UTIs which needs further validation. The role of medicinal plant-based nanotechnology approaches has shown promising results. Therefore, there must be active research in phyto-based therapies of UTIs, such as Ayurvedic Biology.

17 citations

Journal ArticleDOI
TL;DR: Different nanoparticles used in UTI treatment, including organic NPs, nanodiamonds, chemical and green synthesized inorganic NPS, and NPs made of composite materials are discussed, including their potential impact the in the near future.
Abstract: Urinary tract infection (UTI) is one of the most common reasons for antibiotic treatment. Nevertheless, uropathogens are steadily becoming resistant to currently available therapies. In this context, nanotechnology emerges as an innovative and promising approach among diverse strategies currently under development. In this review we deeply discuss different nanoparticles (NPs) used in UTI treatment, including organic NPs, nanodiamonds, chemical and green synthesized inorganic NPs, and NPs made of composite materials. In addition, we compare the effects of different NPs against uropathogens in vivo and in vitro and discuss their potential impact the in the near future.

15 citations

References
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Journal ArticleDOI
TL;DR: The current status of microbial synthesis and applications of metal nanoparticles is presented and several factors such as microbial cultivation methods and the extraction techniques have to be optimized and the combinatorial approach such as photobiological methods may be used.

1,472 citations

Journal ArticleDOI
TL;DR: This is the first evaluation of ZnO, CuO and TiO2 toxicity to bacteria Vibrio fischeri and crustaceans Daphnia magna and Thamnocephalus platyurus with a special emphasis on product formulations (nano or bulk oxides) and solubilization of particles.

1,410 citations


"In vitro bactericidal activity of b..." refers background in this paper

  • ...Specifically, CdS, ZnS, TiO2, SiO2, and CuS are particularly interesting because they are not only stable under harsh process conditions, but also are considered as safe materials to humans.([16]) A number of investigations have empha-...

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Journal ArticleDOI
TL;DR: Treatment of UTIs with antibiotics leads to a more rapid resolution of symptoms and is more likely to clear bacteriuria, but also selects for resistant uropathogens and commensal bacteria and adversely affects the gut and vaginal microbiota.
Abstract: Urinary tract infections (UTIs) are among the most common bacterial infections acquired in the community and in hospitals. In individuals without anatomical or functional abnormalities, UTIs are generally self limiting, but have a propensity to recur. Uropathogens have specialized characteristics, such as the production of adhesins, siderophores and toxins that enable them to colonize and invade the urinary tract, and are transmitted between individuals both through person-to-person contact and possibly via food or water. Although generally self limiting, treatment of UTIs with antibiotics leads to a more rapid resolution of symptoms and is more likely to clear bacteriuria, but also selects for resistant uropathogens and commensal bacteria and adversely affects the gut and vaginal microbiota. As uropathogens are increasingly becoming resistant to currently available antibiotics, it may be time to explore alternative strategies for managing UTI.

1,298 citations


"In vitro bactericidal activity of b..." refers background in this paper

  • ...This infectious disease can alter the urinary system either structurally or functionally.([1]) About 150 million people are diagnosed every year with UTI, costing in excess of 6 billion dollars worldwide....

    [...]

Journal ArticleDOI
TL;DR: Extracellular production of metal nanoparticles by several strains of the fungus Fusarium oxysporum was carried out in this paper, where it was found that aqueous silver ions when exposed to several FUSarium oxyssporum strains are reduced in solution, thereby leading to the formation of silver hydrosol.
Abstract: Extracellular production of metal nanoparticles by several strains of the fungus Fusarium oxysporum was carried out It was found that aqueous silver ions when exposed to several Fusarium oxysporum strains are reduced in solution, thereby leading to the formation of silver hydrosol The silver nanoparticles were in the range of 20–50 nm in dimensions The reduction of the metal ions occurs by a nitrate-dependent reductase and a shuttle quinone extracellular process The potentialities of this nanotechnological design based in fugal biosynthesis of nanoparticles for several technical applications are important, including their high potential as antibacterial material

1,025 citations

Journal ArticleDOI
TL;DR: The problem of antimicrobial resistance in acute uncomplicated community-acquired UTI is highlighted, focusing on TMPSMX resistance, and the few available data regarding clinical outcomes associated with in vitro resistance are summarized.
Abstract: The authors highlight the problem of antimicrobial resistance in acute uncomplicated community-acquired urinary tract infection (UTI), summarize the few available data on clinical outcomes associat...

653 citations


"In vitro bactericidal activity of b..." refers background in this paper

  • ...About 150 million people are diagnosed every year with UTI, costing in excess of 6 billion dollars worldwide.([2]) Bacteria are the major causative agents of UTI....

    [...]