Journal ArticleDOI
In vitro correlate of immunity in a rabbit model of inhalational anthrax.
Margaret L. Pitt,Stephen F. Little,Bruce E. Ivins,P.F. Fellows,J. Barth,John Hewetson,Paul H. Gibbs,Mark T. Dertzbaugh,Arthur M. Friedlander +8 more
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A serological correlate of vaccine-induced immunity was identified in the rabbit model of inhalational anthrax and antibody levels to PA at both 6 and 10 weeks were significant predictors of survival.About:
This article is published in Vaccine.The article was published on 2001-09-14. It has received 267 citations till now. The article focuses on the topics: Anthrax Vaccine Adsorbed & Anthrax vaccines.read more
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Correlates of Protection Induced by Vaccination
TL;DR: This paper attempts to summarize current knowledge about immune responses to vaccines that correlate with protection, finding some vaccines have no true correlates, but only useful surrogates, for an unknown protective response.
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Anthrax as a biological weapon, 2002: updated recommendations for management.
Thomas V. Inglesby,Tara O'Toole,Donald A. Henderson,John G. Bartlett,Michael S. Ascher,Edward M. Eitzen,Arthur M. Friedlander,Julie L. Gerberding,Jerome Hauer,James M. Hughes,Joseph E. McDade,Michael T. Osterholm,Gerald W. Parker,Trish M. Perl,Philip K. Russell,Kevin Tonat +15 more
TL;DR: This revised consensus statement presents new information based on the analysis of the anthrax attacks of 2001, including developments in the investigation of the Anthrax Attacks of 2001; important symptoms, signs, and laboratory studies; new diagnostic clues that may help future recognition of this disease; updated antibiotic therapeutic considerations; and judgments about environmental surveillance and decontamination.
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Correlates of Vaccine-Induced Immunity
TL;DR: Correlates of protection after vaccination are sometimes absolute quantities but often are relative, such that most infections are prevented at a particular level of response but some will occur above that level because of a large challenge dose or deficient host factors.
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Binary Bacterial Toxins: Biochemistry, Biology, and Applications of Common Clostridium and Bacillus Proteins
TL;DR: This review comprehensively surveys the literature and discusses the similarities and distinct differences between each Clostridium and Bacillus binary toxin in terms of their biochemistry, biology, genetics, structure, and applications in science and medicine.
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Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity.
Jennifer A. Maynard,Catharina B.M. Maassen,Stephen H. Leppla,Kathleen M. Brasky,Jean L. Patterson,Brent L. Iverson,George Georgiou +6 more
TL;DR: In vitro, post-challenge protection of macrophages from the action of the holotoxin correlated with the Kd of the scFv variants, and strong correlations among antibody construct affinity, serum half-life, and protection were also observed in a rat model of toxin challenge.
References
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Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
TL;DR: It was shown that phenol red does not interfere with the measurements and no washing steps are required since all ingredients can be added subsequently, and Serum proteins at concentrations up to 25% have no influence on the result.
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The Sverdlovsk anthrax outbreak of 1979
Matthew Meselson,Jeanne Guillemin,Martin Hugh-Jones,Alexander Langmuir,Ilona Popova,Alexis Shelokov,Olga Yampolskaya +6 more
TL;DR: It is concluded that the escape of an aerosol of anthrax pathogen at the military facility caused the outbreak of Sverdlovsk and that most victims worked or lived in a narrow zone extending from a military facility to the southern city limit.
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Demonstration of a capsule plasmid in Bacillus anthracis.
TL;DR: Proof that pXO2 is involved in capsule synthesis came from experiments in which the plasmid was transferred by CP-51-mediated transduction and by a mating system in which plasmids transfer is mediated by a Bacillus thuringiensis fertility plasmide, pXo12.
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The collison nebulizer: Description, performance and application
TL;DR: The Collison nebulizer as discussed by the authors is widely used to produce fine aerosols from a liquid supply and details of its design and operating characteristics are given, including air and liquid consumption, aerosol output rate and droplet size distribution.
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Iraq's biological weapons. The past as future?
TL;DR: The international community must be firm in its enforcement of United Nations resolutions designed to deter Iraq from reacquiring biological warfare capability and must take steps to develop a multidisciplinary approach to limiting future development of weapons of mass destruction.