In vitro evaluation of nanoplastics using human lung epithelial cells, microarray analysis and co-culture model.
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TLDR
Wang et al. as discussed by the authors used two types of human lung epithelial cells (bronchial epithelium transformed with Ad12-SV40 2B, BEAS-2B) to investigate the association between lung injury and polystyrene nanoplastics.About:
This article is published in Ecotoxicology and Environmental Safety.The article was published on 2021-10-04 and is currently open access. It has received 39 citations till now. The article focuses on the topics: Lung injury & Lung.read more
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COVID-19-related personal protective equipment (PPE) contamination in the highly urbanized southeast Brazilian coast
TL;DR: In this paper , a study aimed to report personal protective equipment (PPE) contamination in Santos beaches (Brazil) using standardized procedures for the first time while comparing two periods to understand the progression of PPE contamination.
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A study on the roles of long non-coding RNA and circular RNA in the pulmonary injuries induced by polystyrene microplastics.
TL;DR: In this article , the authors investigated the role of polystyrene microplastics (PS-MPs) in the development of lung inflammation caused by inhaling them and found that the upregulated expression of IL-6, TNF-α and IL-1β were upregulated in the lungs of exposed rats.
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Impact of waste of COVID-19 protective equipment on the environment, animals and human health: a review
TL;DR: In this paper , the authors reviewed the threat of protective equipment associated plastic and microplastic wastes to environments, animals and human health, and revealed the protection equipment associated micro-plastic cycle, and provided several recommendations and future research priority for the sustainable environment.
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How Nanoparticles Open the Paracellular Route of Biological Barriers: Mechanisms, Applications, and Prospects.
Junrong Wu,Zhenjun Zhu,Wenjing Liu,Yanli Zhang,Yiyuan Kang,Jia Hui Liu,Chen Hu,Ruolan Wang,Manjin Zhang,Lili Chen,Longquan Shao +10 more
TL;DR: The in-depth causes for the reversible opening or destruction of the integrity of barriers generated by NPs are demonstrated and insights into the design of NP-based medications to boost paracellular drug delivery efficiency are contributed.
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Toxicity of micro(nano)plastics with different size and surface charge on human nasal epithelial cells and rats via intranasal exposure.
Jiayu Huang,Guangyuan Dong,Miaoting Liang,Xidong Wu,Mingjian Xian,Yunsong An,Jiandong Zhan,Lingling Xu,Jindong Xu,Wei Yao Sun,Shaohua Chen,Chengyu Chen,Tao Li +12 more
TL;DR: In this article , the in vitro toxicity of thirteen polystyrene MNPs with different surface functionalization (carboxylic (C-PS), amino (A-PS, and bare (PS)) and sizes (20-2000 nm) on human nasal epithelial cells (HNEpCs) at 10-1250 μg/mL as well as their in vivo toxicity to rats via intranasal administration at 125 μg/ mL.
References
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Reactive oxygen species in cell signaling
TL;DR: The evidence for ligand-induced generation of ROS, its cellular sources, and the signaling pathways that are activated is examined.
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TL;DR: A critical analysis of the challenges and limitations of the most widely used fluorescent probes for detecting and measuring reactive oxygen and nitrogen species and proposed guidelines that will help present and future researchers with regard to the optimal use of selected fluorescent probes and interpretation of results are presented.
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Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines.
TL;DR: It is demonstrated that only ultrafine polystyrene particles induced a significant increase in cytosolic calcium ion concentration and experiments using dichlorofluorescin diacetate demonstrated greater oxidant activity of the ultrafine particles, which may explain their activity in these assays.
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Microplastics as an emerging threat to terrestrial ecosystems
Anderson Abel de Souza Machado,Anderson Abel de Souza Machado,Werner Kloas,Werner Kloas,Christiane Zarfl,Stefan Hempel,Matthias C. Rillig +6 more
TL;DR: The pervasive microplastic contamination as a potential agent of global change in terrestrial systems is introduced, the physical and chemical nature of the respective observed effects are highlighted, and the broad toxicity of nanoplastics derived from plastic breakdown is discussed.
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Mechanisms of cell death in oxidative stress.
Stefan W. Ryter,Hong Pyo Kim,Alexander Hoetzel,Jeong W. Park,Kiichi Nakahira,Xue Wang,Augustine M.K. Choi +6 more
TL;DR: Cell death mechanisms have been studied across a broad spectrum of models of oxidative stress, including H2O2, nitric oxide and derivatives, endotoxin-induced inflammation, photodynamic therapy, ultraviolet-A and ionizing radiations, and cigarette smoke.