In-Vivo and In-Vitro Conversion of Angiotensin I to Angiotensin II in Dog Blood
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...Other investigators (23, 29) found about the same percent conversion in the dog in vivo....
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...Other workers confirmed the importance of the lung in the conversion of angiotensin I, but they found greater converting activity in the renal (20-23), peripheral (24, 25), and splanchnic (26) circulation than was suspected from the initial research....
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413 citations
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References
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"In-Vivo and In-Vitro Conversion of ..." refers methods in this paper
...The conversion of angiotensin I to angiotensin II in whole blood and in the intact dog was examined by radioimmunoassay techniques (8, 9)....
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...This combination has been shown (8) to be effective in inhibiting angiotensin I conversion and angiotensinase activity in plasma....
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945 citations
"In-Vivo and In-Vitro Conversion of ..." refers background in this paper
...(12) on converting enzyme isolated from horse plasma....
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...Plasma (12) and extracts of several organs of the rat, including kidney, ileum, liver, heart, and brain, as well as the* lung (13), have converting enzyme activity, the physiologic significance of which is questionable....
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571 citations
"In-Vivo and In-Vitro Conversion of ..." refers background or methods or result in this paper
...Our results derived from radioactive peptide measurements were comparable to those of Ng and Vane (3) with heparinized whole blood for short incubation times (8 vs....
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...Thus, the lung is considered the principal site of formation of circulating angiotensin II (3)....
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...An increase in biologic activity of angiotensin I has been observed after a single passage through the pulmonary circulation (3-7)....
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...Our finding of extensive conversion in the intact pulmonary circulation confirms the observations of others (3-7) using bioassay techniques....
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...Angiotensin I conversion proceeds at a much slower rate in extracorporeal blood than in the intact animal (3)....
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295 citations
"In-Vivo and In-Vitro Conversion of ..." refers background or methods or result in this paper
...Angiotensin II inactivation has been demonstrated in intact (4, 10, 15) and isolated perfused (16) kidneys....
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...Our finding of extensive conversion in the intact pulmonary circulation confirms the observations of others (3-7) using bioassay techniques....
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...An increase in biologic activity of angiotensin I has been observed after a single passage through the pulmonary circulation (3-7)....
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...Angiotensin I conversion has not been demonstrated in femoral, carotid, renal, or total peripheral vascular beds of the intact animal or the isolated perfused kidney by the blood-bathed organ technique (4, 10)....
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236 citations
"In-Vivo and In-Vitro Conversion of ..." refers background in this paper
...In addition, angiotensin Iconverting activity has been demonstrated in cell-free extracts of lung tissue (11)....
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