In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota
Lisa M Bode,Diana Bunzel,Melanie Huch,Gyu-Sung Cho,Denise Ruhland,Mirko Bunzel,Achim Bub,Charles M. A. P. Franz,Sabine E. Kulling +8 more
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TLDR
Trans-Resveratrol metabolism by human gut microbiota shows pronounced interindividual differences, which should be taken into account during investigation of health-related effects of this stilbene.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2013-02-01 and is currently open access. It has received 301 citations till now. The article focuses on the topics: Metabolite.read more
Citations
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Resveratrol: A Double-Edged Sword in Health Benefits
Bahare Salehi,Abhay Prakash Mishra,Manisha Nigam,Bilge Sener,Mehtap Kilic,Mehdi Sharifi-Rad,Patrick Valere Tsouh Fokou,Natália Martins,Javad Sharifi-Rad,Javad Sharifi-Rad +9 more
TL;DR: This review summarized current data on resveratrol pharmacological effects and confirmed its anticancer properties, as well as other bioactive effects, namely as anti-inflammatory, anticarcinogenic, cardioprotective, vasorelaxant, phytoestrogenic and neuroprotective.
Journal ArticleDOI
The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility
TL;DR: This review focuses on the biotransformation of polyphenols by gut microbiota, modulation of gut microbiota bypolyphenols, and the effects of these two-way mutual interactions on polyphenol bioavailability, and ultimately, human health.
Journal ArticleDOI
Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update
Ana Rodriguez-Mateos,David Vauzour,Christian G. Krueger,Dhanansayan Shanmuganayagam,Jess D. Reed,Luca Calani,Pedro Mena,Daniele Del Rio,Alan Crozier +8 more
TL;DR: Recent findings on the bioavailability and biological activity of (poly)phenols are summarized, focusing on the epidemiological and clinical evidence of beneficial effects of flavonoids and related compounds on urinary tract infections, cognitive function and age-related cognitive decline, cancer and cardiovascular disease.
Journal ArticleDOI
Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence.
Joao Tomé-Carneiro,Mar Larrosa,Antonio González-Sarrías,Francisco A. Tomás-Barberán,María Teresa García-Conesa,Juan Carlos Espín +5 more
TL;DR: This review will focus on the currently available evidence regarding resveratrol’s effects on humans obtained from randomized clinical trials and provide a critical outlook for further research on this molecule that is evolving from a minor dietary compound to a possible multi-target therapeutic drug.
Journal ArticleDOI
Role of Intestinal Microbiota in the Bioavailability and Physiological Functions of Dietary Polyphenols.
TL;DR: The intestinal microbiota is a key factor in mediating the physiological functions of dietary polyphenols, resulting in health promotion by the activation of short chain fatty acids excretion and intestinal immune function.
References
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Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
Journal ArticleDOI
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Mei-Shiang Jang,Lining Cai,George Udeani,Karla Slowing,Cathy F. Thomas,Chris Beecher,Harry H. S. Fong,Norman R. Farnsworth,A. Douglas Kinghorn,Rajendra G. Mehta,Richard C. Moon,John M. Pezzuto +11 more
TL;DR: It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
Journal ArticleDOI
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur,Kevin J. Pearson,Nathaniel O Price,Hamish A. Jamieson,Carles Lerin,Avash Kalra,Vinayakumar Prabhu,Joanne S. Allard,Guillermo López-Lluch,Kaitlyn N. Lewis,Paul J. Pistell,Suresh Poosala,Kevin G. Becker,Olivier Boss,Dana M. Gwinn,Mingyi Wang,Sharan Ramaswamy,Kenneth W. Fishbein,Richard G. Spencer,Edward G. Lakatta,David G. Le Couteur,Reuben J. Shaw,Plácido Navas,Pere Puigserver,Donald K. Ingram,Rafael de Cabo,David A. Sinclair +26 more
TL;DR: It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.
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NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities.
TL;DR: 1H and 13C chemical shifts of what are, in the authors' experience, the most popular “extra peaks” in a variety of commonly used NMR solvents are collected, in the hope that this will be of assistance to the practicing chemist.
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Rapid extraction of bacterial genomic DNA with guanidium thiocyanate
TL;DR: The method, which was applicable to both Gram‐positive and Gram‐negative bacteria, eliminated endogenous nuclease activity and avoided the need for phenol, RNase and protease treatments.
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