Journal ArticleDOI
In vivo antitumor, in vitro antibacterial activity and alkylating properties of phosphorohydrazine derivatives of coumarin and chromone.
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TLDR
Compounds 4b-c/5a-c and 9a demonstrated in vitro antitumor activity against P388 leukemia and Antineoplastic activity of the compounds 4b/5b and9a combined with methotrexate was showed using L1210 murine leukemia.About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2006-11-01. It has received 172 citations till now. The article focuses on the topics: Chromone & Antibacterial agent.read more
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Chromone: A Valid Scaffold in Medicinal Chemistry
Alexandra Gaspar,Alexandra Gaspar,Maria João Matos,Maria João Matos,Jorge Garrido,Jorge Garrido,Eugenio Uriarte,Fernanda Borges +7 more
TL;DR: This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013) and SFRH/BD/61262/2009.
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Current developments of coumarin-based anti-cancer agents in medicinal chemistry
Saeed Emami,Sakineh Dadashpour +1 more
TL;DR: The current developments of coumarin-based anticancer agents are covered and the structure-activity relationship of the most potent compounds are discussed.
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Chromones as a privileged scaffold in drug discovery: a review.
TL;DR: The present review focuses on the pharmacological profile of chromone derivatives in the current literature with an update of recent research findings on this nucleus and the perspectives that they hold for future research.
Journal ArticleDOI
Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids
TL;DR: A detailed account of the design strategies employed for the synthesis of anticancer agents via molecular hybridization techniques is offered and the structure activity relationship along with mechanistic insights revealed during the biological evaluation of the hybrids are highlighted.
Journal ArticleDOI
Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents
Suresh Khode,Veeresh Maddi,Prashant Aragade,Mahesh B. Palkar,Pradeep Kumar Ronad,Shivalingarao Mamledesai,A. H. M. Thippeswamy,Darbhamulla Satyanarayana +7 more
TL;DR: A novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines (3a-l) found to have significant analgesic activity in the acetic acid induced writhing model and antipyreticActivity in yeast-induced pyrexia model along with minimum ulcerogenic index.
References
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Studies on antianaphylactic agents—III
TL;DR: By the application of the Vilsmeier-Haack reaction to various o-hydroxyacetophenone derivatives, 4-oxo-4H-1-benzopyran-3-carboxaldehydes were synthesized in one step as discussed by the authors.
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Structure–activity relationships of some 3-substituted-4-hydroxycoumarins as HIV-1 protease inhibitors
Serge Kirkiacharian,Duong Thanh Thuy Duong Thanh Thuy,Sames Sicsic,Robert Bakhchinian,Raffi Kurkjian,Thierry Tonnaire +5 more
TL;DR: The data indicate the importance of substituents at positions 5 and 7 of the coumarin ring on the inhibitory potency of the HIV-1-PR.
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Cytotoxic effects, alkylating properties and molecular modelling of coumarin derivatives and their phosphonic analogues.
TL;DR: Using regression analysis QSAR, a relationship between biological activity and the physicochemical properties of the test compounds is found and their cytotoxic effect increases with an increase of the hydrophobic parameters in the region of the substituents at the 2-, 3- and 4-positions of the benzopyrone skeleton of 4-6.
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Decrease of cyclin D1 in the human lung adenocarcinoma cell line A-427 by 7-hydroxycoumarin
Fausto Alejandro Jiménez-Orozco,Jose Sullivan Lopez-Gonzalez,Alejandro Nieto-Rodrı́guez,Marco A. Velasco-Velázquez,Juan Molina-Guarneros,Nicandro Mendoza-Patiño,Marı́a Juana Garcı́a-Mondragón,Patricia Elizalde-Galvan,Fernando León-Cedeño,Juan José Mandoki +9 more
TL;DR: In this paper, the effects of coumarin and 7-hydroxycoumarin in the human lung adenocarcinoma cell line A-427 on the inhibition of cell proliferation, cell cycle progression, and expression of cyclins D1, E and A were studied.