Inactivation of MTOR promotes autophagy-mediated epithelial injury in particulate matter-induced airway inflammation.
Citations
2,014 citations
45 citations
45 citations
28 citations
25 citations
References
7,092 citations
"Inactivation of MTOR promotes autop..." refers background in this paper
...Recently, several studies have already demonstrated that PM is able to deposit in the respiratory tract or come into alveoli, consequently induces impairment of airway epithelial barrier, oxidative stress, autophagy, DNA damage, and genomic instability [3,4]....
[...]
4,719 citations
2,352 citations
2,014 citations
"Inactivation of MTOR promotes autop..." refers background in this paper
...Generally, MTOR complex 1 is considered as the master regulator of autophagy [5,6]....
[...]
...Extensive studies have established a dominant role for MTOR in regulating cellular growth and metabolism in response to growth factors and nutrients, and reveal that MTOR signaling pathway is implicated in the progression of cancer, obesity, type 2 diabetes, as well as the aging process [5]....
[...]
1,081 citations
"Inactivation of MTOR promotes autop..." refers background in this paper
...Additionally, IL6 induces the production of proinflammatory cytokines such as IL17 and IL23 via IL6RA (interleukin 6 receptor, alpha) in mature neutrophils to establish a Th17 cells-polarizing positive feedback loop [32,34]....
[...]