Incidence and clinical importance of perioperative histamine release: randomised study of volume loading and antihistamines after induction of anaesthesia
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12 citations
Cites background or methods or result from "Incidence and clinical importance o..."
...Two sets of conditions were included: a complex clinical scenario (postinduction period of anaesthesia and minor operation [4]) and those of trial design with 4 groups and simple, balanced randomisation [5]....
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...Ranitidine and famotidine in combination with dimetindene were ineffective whereas cimetidine reduced histamine release as in the clinical trial [4] (Fig....
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...5 mg/kg 48/80, similar to Haemaccel [4])....
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...Random key not opened before classification of reactions [4]....
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...Cardiorespiratory disturbances (histamine-related and unrelated) were found following infusion of the plasma substitute (Ringer containing 48/80) with the same success as in the clinical trial [4]....
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12 citations
Cites background or methods or result from "Incidence and clinical importance o..."
...1 mg/kg dimetindene (Fenistil®) and 5 mg/kg cimetidine (Tagamet®) at least 15 min before induction of anaesthesia [14]....
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...On day 3 after operation the effectiveness of blinding has to be assessed [14, 29]....
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...Organistional structure similar to the Mainz-Marburg trial [14]....
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...Routine follow up of the postoperative course The course after operation up to the day of discharge will be recorded in the protocol shown in Table 4 [14, 29]....
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...A patient record file (PRF) will be used which has already been proven suitable in the antihistamine Mainz-Marburg Trial [14, 29]....
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12 citations
References
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