Incidence and Prevalence of Childhood Epilepsy: A Nationwide Cohort Study
Kari Modalsli Aaberg,Kari Modalsli Aaberg,Nina Gunnes,Inger Johanne Bakken,Camilla Lund Søraas,Aleksander Berntsen,Per Magnus,Morten I. Lossius,Camilla Stoltenberg,Camilla Stoltenberg,Richard F.M. Chin,Richard F.M. Chin,Pål Surén,Pål Surén +13 more
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TLDR
About 1 out of 150 children is diagnosed with epilepsy during the first 10 years of life, with the highest incidence rate observed during infancy, in the Norwegian Mother and Child Cohort Study.Abstract:
BACKGROUND AND OBJECTIVES: Epilepsy affects 0.5% to 1% of children and is the most frequent chronic neurologic condition in childhood. Incidence rates appear to be declining in high-income countries. The validity of epilepsy diagnoses from different data sources varies, and contemporary population-based incidence studies are needed. METHODS: The study was based on the Norwegian Mother and Child Cohort Study. Potential epilepsy cases were identified through registry linkages and parental questionnaires. Cases were validated through medical record reviews and telephone interviews of parents. RESULTS: The study population included 112 744 children aged 3 to 13 years (mean 7.4 years) at end of registry follow-up (December 31, 2012). Of these, 896 had registry recordings and/or questionnaire reports of epilepsy. After validation, 587 (66%) met the criteria for an epilepsy diagnosis. The incidence rate of epilepsy was 144 per 100 000 person-years in the first year of life and 58 per 100 000 for ages 1 to 10 years. The cumulative incidence of epilepsy was 0.66% at age 10 years, with 0.62% having active epilepsy. The 309 children (34%) with erroneous reports of epilepsy from the registry and/or the questionnaires had mostly been evaluated for nonepileptic paroxysmal events, or they had undergone electroencephalography examinations because of other developmental or neurocognitive difficulties. CONCLUSIONS: Approximately 1 out of 150 children is diagnosed with epilepsy during the first 10 years of life, with the highest incidence rate observed during infancy. Validation of epilepsy diagnoses in administrative data and cohort studies is crucial because reported diagnoses may not meet diagnostic criteria for epilepsy.read more
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The Norwegian Patient Registry and the Norwegian Registry for Primary Health Care: Research potential of two nationwide health-care registries:
Inger Johanne Bakken,Anja Maria Steinsland Ariansen,Gun Peggy Knudsen,Knut Ivar Johansen,Stein Emil Vollset,Stein Emil Vollset +5 more
TL;DR: An overview of the history and content of the Norwegian Patient Registry and its research possibilities is given and the NRPHC is introduced as a possible future research tool and the potential for studying patient trajectories when combining data from the two registries.
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Global Burden of Childhood Epilepsy, Intellectual Disability, and Sensory Impairments
Bolajoko O. Olusanya,Scott M. Wright,M. K. C. Nair,Nem-Yun Boo,Ricardo Halpern,Hannah Kuper,Amina Abubakar,Nihad A. Almasri,Jalal Arabloo,Narendra K. Arora,Sophia Backhaus,Brad D. Berman,Cecilia Breinbauer,G. L. Carr,Petrus J. de Vries,Christie del Castillo-Hegyi,Aziz Eftekhari,Melissa Gladstone,Rosa A. Hoekstra,Vijaya Kancherla,Mphelekedzeni C. Mulaudzi,Angelina Kakooza-Mwesige,Felix Akpojene Ogbo,Helen E Olsen,Jacob Olusegun Olusanya,Ashok Pandey,Maureen Samms-Vaughan,Chiara Servili,Amira Shaheen,Tracey Smythe,Donald Wertlieb,Andrew N Williams,Charles R. Newton,Adrian Davis,Nicholas J Kassebaum +34 more
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Impact of predictive, preventive and precision medicine strategies in epilepsy.
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Use of ketogenic diet therapy in infants with epilepsy: A systematic review and meta-analysis.
TL;DR: This systematic review of studies that have reported on response to Ketogenic diet therapy in infants with epilepsy aimed to systematically review the efficacy of KDT in infants.
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Seizures, syndromes, and etiologies in childhood epilepsy: The International League Against Epilepsy 1981, 1989, and 2017 classifications used in a population-based cohort
Kari Modalsli Aaberg,Kari Modalsli Aaberg,Pål Surén,Pål Surén,Camilla Lund Søraas,Inger Johanne Bakken,Morten I. Lossius,Morten I. Lossius,Camilla Stoltenberg,Camilla Stoltenberg,Richard F.M. Chin,Richard F.M. Chin +11 more
TL;DR: The study provides updated information about the distribution of seizures, epilepsies, and etiologies of epilepsy in the general child population, and compares the old and new classification systems from the International League Against Epilepsy (ILAE).
References
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Incidence of Epilepsy and Unprovoked Seizures in Rochester, Minnesota: 1935–1984
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Journal Article
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