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Journal ArticleDOI

Include mushroom in daily diet—A strategy for better hepatic health

02 Jan 2016-Food Reviews International (Taylor & Francis)-Vol. 32, Iss: 1, pp 68-97
TL;DR: This review summarizes the medicinal value of different edible mushrooms on free radical–, xenobiotic-, and drug-induced hepatotoxicity.
Abstract: Liver, the most important metabolic organ of the body, is also the major organ for the detoxification of the blood stream. If the accumulation of toxins is faster than their removal by liver, hepatic damage occurs. Although synthetic drugs are available in the market, long-term use of such drugs has consequential side effects. Therefore, the growing need to find safe, cost-effective drugs devoid of adverse effects is spawning extensive research. Mushrooms are rising as a major medicinal food and pharmaceuticals. This review summarizes the medicinal value of different edible mushrooms on free radical–, xenobiotic-, and drug-induced hepatotoxicity.
Citations
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Journal ArticleDOI
Faruque Ahmad1
TL;DR: The present review is an effort to investigate and compile the reported biologically active compounds, pharmacological activity, toxicity and comparative study of different medicinal mushrooms.

146 citations

Journal ArticleDOI
TL;DR: This is the first review presenting morels' nutritional and phytochemical composition, health benefits and flavor, and it will review the available information in current literature regarding these aspects in light of morels phenotypic plasticity.
Abstract: Morels are edible mushrooms appreciated worldwide for their savory flavor. Morels have been in use in traditional medicine for centuries, due to their health-related benefits, and current research demonstrated their anti-oxidative and anti-inflammatory bioactivities, in addition to immunostimulatory and anti-tumor properties. In spite of the high demand for morels and their increasing economic importance, their cultivation is limited, and they are either used as wild harvested or fermented in culture, for consumption as a functional food and for food-flavoring. Morel's health benefits were attributed mainly to polysaccharides as the active compounds, and to various phytochemicals, mainly phenolic compounds, tocopherols, ascorbic acid and vitamin D. Morel's nutritional composition was reported, including sugar, amino acid, fatty and organic acid and mineral profile. Information regarding Morel's flavor is limited, and while some of their taste attributes have been described, including the role of u...

89 citations


Cites background from "Include mushroom in daily diet—A st..."

  • ...…activities were also reported (Lindequist et al., 2005, Alves et al., 2012, Roupas et al., 2012), as well as their anti-diabetic, cardiovascular, and hepatoprotective effects (Wasser and Weis, 1999, Guillam on et al., 2010, Wasser, 2010, Roupas et al., 2012, Chatterjee and Acharya, 2016)....

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  • ...…as well as confirmed some of their medicinal features (Gao, 2006, Barros et al., 2008, Zhong and Xiao, 2009, Greve et al., 2010, Stajic et al., 2013, Beekman and Barrow, 2014, Evidente et al., 2014, Giavasis, 2014, Huang and Nie, 2015, Zhang, 2015, Chatterjee and Acharya, 2016, Zhang et al., 2016)....

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Journal ArticleDOI
TL;DR: The present review overviews and complies current knowledge and trends of nutrients as well as bioactive mushroom components including the potential of Huitlacoche and ergothioneine, and the possible health benefits of these biological products and their activities have been explored which enhances the utilization of mushrooms.

36 citations

Journal ArticleDOI
TL;DR: The use of medicinal mushrooms for treatment of DM and in prevention development of its secondary complications might be a new effective approach of this disease’s cure.
Abstract: Diabetes mellitus (DM) is the third most common non-infectious disease leading to early disability and high mortality Moreover, the number of patients is growing every year The main symptom of DM is hyperglycemia Increased levels of blood glucose activate polyol, hexosamine, and protein kinase metabolic pathways cause the intensification of non-enzymatic glycosylation and nitration of macromolecules This, in turn, leads to the development of oxidative and nitrative stresses and secondary complications, such as different kinds of micro- and macroangiopathies Metabolic disorders caused by insulin deficiency in diabetes significantly impede the functioning of a homeostasis system, which change the physical, biochemical, morphological, and functional properties of blood cells As a result, the oxygen-transport function of red blood cells (RBCs), rheological properties of the blood, and functions of immunocompetent cells as well as the process of apoptosis are primarily affected Modern pharmacotherapy focuses on the search for new preparations that aim to decrease blood glucose levels Undesirable side effects and adverse reactions caused by synthetic medicines led to the search and investigation of new preparations of natural origin Medicinal mushrooms play an important role among such new preparations They are a source of a large number of high- and low-molecular compounds with pronounced biological effects Our investigations show pronounced hypoglycemic and anti-anemic action of submerged cultivated mycelium powder of medicinal mushrooms Agaricus brasiliensis (A brasiliensis) and Ganoderma lucidum (G lucidum) on streptozotocin-induced DM in rats Also, we showed that mycelium powders have membrane protective properties as evidenced by the redistribution of RBC populations towards the growth of full functional cell numbers Normalization of parameters of leukocyte formula and suppression of apoptosis of white blood cells in diabetic rats treated with A brasiliensis and G lucidum mycelia indicates pronounced positive effects of these strains of mushrooms Thus, the use of medicinal mushrooms for treatment of DM and in prevention development of its secondary complications might be a new effective approach of this disease's cure This article is aimed at summarizing and analyzing the literature data and basic achievements concerning DM type 1 treatment using medicinal mushrooms and showing the results obtained in our research

32 citations

Journal ArticleDOI
TL;DR: This is the first report on chemical composition and antioxidant activity of different crude polysaccharides from M. gigantea and it can be inferred that HWP may foster further studies for searching active compound which might be used as ingredients of functional foods, nutraceuticals and pharmaceuticals.
Abstract: Polysaccharides from mushrooms are potentially active pharmaceutical ingredients and their action is dependent upon conformation, composition, size etc. In this context, three water soluble crude polysaccharide rich fractions viz. hot water extracted polysaccharide (HWP), cold alkaline extracted polysaccharide (CAP) and hot alkaline extracted polysaccharide (HAP) have been isolated using varying extraction parameters from Macrocybe gigantea, a well-known edible mushroom collected from Gangetic plain of West Bengal and authenticated by DNA barcoding of nrDNA ITS region. Physico-chemical investigation revealed that the fractions were mainly composed of β-configuration in pyranose form of sugars conjugated with small amount of protein. Further analysis presented that polysaccharides were composed of same monosaccharide even in similar order of ratio (D-glucose > D-galactose > D-mannose > D-xylose). However, D-glucose as well as β-glucan were found to be in the highest amount in CAP. The helical structure was determined by Congo red assay which indicated that polysaccharides were in aggregate forms except HWP which consisted of tertiary structure. These diverse structural features may have imparted effect on free radical scavenging activity of polysaccharides where HWP was the most active in all assays. HWP was proved to be a good scavenger of free radicals, strong chelator of ferrous ion and had high reducing power. Thus it can be inferred that HWP may foster further studies for searching active compound which might be used as ingredients of functional foods, nutraceuticals and pharmaceuticals. Moreover, to the best of our knowledge this is the first report on chemical composition and antioxidant activity of different crude polysaccharides from M. gigantea.

23 citations


Cites background from "Include mushroom in daily diet—A st..."

  • ...R. Heim; Termitomyces medius R. Heim & Grassé etc. (Khatua et al. 2013, 2015; Chatterjee and Acharya 2015; Patra et al. 2012)....

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References
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Journal ArticleDOI
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Abstract: The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors, particularly smoking, in economically developing countries. Based on the GLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths are estimated to have occurred in 2008; of these, 56% of the cases and 64% of the deaths occurred in the economically developing world. Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths. Lung cancer is the leading cancer site in males, comprising 17% of the total new cancer cases and 23% of the total cancer deaths. Breast cancer is now also the leading cause of cancer death among females in economically developing countries, a shift from the previous decade during which the most common cause of cancer death was cervical cancer. Further, the mortality burden for lung cancer among females in developing countries is as high as the burden for cervical cancer, with each accounting for 11% of the total female cancer deaths. Although overall cancer incidence rates in the developing world are half those seen in the developed world in both sexes, the overall cancer mortality rates are generally similar. Cancer survival tends to be poorer in developing countries, most likely because of a combination of a late stage at diagnosis and limited access to timely and standard treatment. A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination (for liver and cervical cancers), and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake. Clinicians, public health professionals, and policy makers can play an active role in accelerating the application of such interventions globally.

52,293 citations

Journal ArticleDOI
Rafael Lozano1, Mohsen Naghavi1, Kyle J Foreman2, Stephen S Lim1  +192 moreInstitutions (95)
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex, using the Cause of Death Ensemble model.

11,809 citations

01 Jan 2003

11,232 citations


"Include mushroom in daily diet—A st..." refers background in this paper

  • ...74 million deaths).((30)) About 70% of all cancer deaths occur in lowand middle-income countries....

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Journal ArticleDOI
TL;DR: HBV and HCV infections account for the majority of cirrhosis and primary liver cancer throughout most of the world, highlighting the need for programs to prevent new infections and provide medical management and treatment for those already infected.

2,385 citations


"Include mushroom in daily diet—A st..." refers background in this paper

  • ...(HCC) represents the major histological subtype, accounting for 70–85% of the total hepatic cancer burden worldwide.((33)) Population-based studies show that the incidence rate continues to approximate death rate, indicating that most of the patients who develop HCC die of it....

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