scispace - formally typeset
Open AccessJournal ArticleDOI

Inconsistent effects of sleep deprivation on memory function.

Reads0
Chats0
TLDR
In this article, the role of sleep deprivation in learning and memory processing in basic and clinical studies is discussed, and the authors compare the similar mechanisms between the impairment and the improvement effects of sleep loss.
Abstract
In this review article, we aimed to discuss the role of sleep deprivation (SD) in learning and memory processing in basic and clinical studies. There are numerous studies investigating the effect of SD on memory, while most of these studies have shown the impairment effect of SD. However, some of these studies have reported conflicting results, indicating that SD does not impair memory performance or even improves it. So far, no study has discussed or compared the conflicting results of SD on learning and memory. Thus, this important issue in the neuroscience of sleep remains unknown. The main goal of this review article is to compare the similar mechanisms between the impairment and the improvement effects of SD on learning and memory, probably leading to a scientific solution that justifies these conflicting results. We focused on the inconsistent effects of SD on some mechanisms involved in learning and memory, and tried to discuss the inconsistent effects of SD on learning and memory.

read more

Citations
More filters
Journal ArticleDOI

Do Sleep Disturbances have a Dual Effect on Alzheimer’s Disease?

TL;DR: The role of sleep disturbances and Alzheimer's disease in the regulation of synaptic plasticity, oxidative stress, neuroinflammation, and clock genes expression is discussed and the potential dualistic role ofSleep disturbances in the pathogenesis of Alzheimer's Disease is evaluated.
Journal ArticleDOI

The role of sleep deprivation in streptozotocin-induced Alzheimer’s disease-like sporadic dementia in rats with respect to the serum level of oxidative and inflammatory markers

TL;DR: The results showed that only 24 h SD impaired spatial learning and memory in rats, and it is suggested that STZ has more important mechanisms that are involved in its memory impairment effect, and maybe, STZ-induced inflammation has a more important role.
Journal ArticleDOI

Temporary amnesia from sleep loss: A framework for understanding consequences of sleep deprivation

TL;DR: In this article , an alternative framework was proposed to understand sleep loss and memory in terms of temporary amnesia from sleep loss (TASL), which encourages movement away from traditional explanations based on narrowly defined domains of memory functioning and taking instead a more expansive view of how brain structures that support memory, such as the hippocampus, interact with higher structures to produce complex cognition and behavioral performance.
Journal ArticleDOI

Effect of multi-epitope derived from HIV-1 on REM sleep deprivation-induced spatial memory impairment with respect to the level of immune factors in mice.

TL;DR: In this article , the effect of multi-epitope Gag-Pol-Env-Tat derived from Human immunodeficiency virus 1 (HIV-1) on rapid-eye-movement (RSD) induced spatial memory impairment with respect to the levels of interleukin-4 (IL-4), interleungin-17 ( IL-17), interferon-gamma (IFN-γ), immunoglobulin G1 (IgG1), and lymphocyte proliferation in NMRI mice.
References
More filters
Journal ArticleDOI

Brain-derived Neurotrophic Factor

TL;DR: Since the purification of BDNF in 1982, a great deal of evidence has mounted for its central roles in brain development, physiology, and pathology, and application of the trophic properties ofBDNF may lead to novel therapeutic options in neurodegenerative diseases and perhaps even in neuropsychiatric disorders.
Journal ArticleDOI

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

TL;DR: It is suggested that BDNF might have a functional role in the expression of LTP in the hippocampus, and the magnitude of the potentiation, as well as the percentage of cases in which LTP could be induced successfully, was clearly affected.
Journal ArticleDOI

Interacting Molecular Loops in the Mammalian Circadian Clock

TL;DR: Analysis of Clock/Clock mutant mice, homozygous Period2(Brdm1) mutants, and Cryptochrome-deficient mice reveals substantially altered Bmal1 rhythms, consistent with a dominant role of PERIOD2 in the positive regulation of the Bmal 1 loop.
Journal ArticleDOI

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

TL;DR: It is demonstrated that treatment of hippocampal slices from BDNF knockout mice with recombinant BDNF completely reverses deficits in long-term potentiation and significantly improves deficits in basal synaptic transmission at the Schaffer collateral-CA1 synapse, indicating that BDNF has an acute role in hippocampal synaptic function.
Journal ArticleDOI

The human emotional brain without sleep — a prefrontal amygdala disconnect

TL;DR: Functional magnetic resonance image (fMRI) scans have obtained evidence that a lack of sleep inappropriately modulates the human emotional brain response to negative aversive stimuli.
Related Papers (5)
Trending Questions (1)
What are the effects of inconsistent sleep on health?

The effects of inconsistent sleep on health are not discussed in the provided information.