Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo
Citations
759 citations
Cites background from "Increased content and transport of ..."
...After the depletion of sensory neuropeptides from nerve terminals following treatment with the TRPV1 agonist capsaicin, NGF is required for the synthesis of new peptide (97)....
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729 citations
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...…increase NGF supply from the periphery (Woolf et al., 1994; Fukuoka et al., 2001) and upregulate expression of substance P, calcitonin-gene related peptide (CGRP), and BDNF by TrkA-expressing neurons in the DRG (Donnerer et al., 1992; Cho et al., 1997; Fukuoka et al., 2000; Fukuoka et al., 2001)....
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596 citations
578 citations
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...seen after inflammation (Donnerer et al., 1992)....
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...It is known, for example, that NGF production is greatly increased in inflamed tissue (Weskamp and Otten, 1987), and may be responsible for the upregulation of neuropeptide seen after inflammation (Donnerer et al., 1992)....
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576 citations
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...This is mediated indirectly via several mechanisms including prostanoid release, increasing the expression of NGF or bradykinin receptors, or by affecting sympathetic fibres [12, 13, 27]....
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...In keeping with this, anti-NGF antibodies reduce the hyperalgesia and neurochemical changes induced by NGF and inflammation [30, 58]....
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...Histamine can be released following mast cell degranulation by a number of inflammatory mediators including substance P, interleukin-1 (IL1) and NGF....
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...NGF increases the synthesis of several neuropeptides including neurokinins and CGRP and regulates a number of other proteins such as the capsaicin receptor, membrane Na channels and proton-activated ion channels [2, 43]....
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...Thus, protons and capsaicin activate sensory membranes through identical ionic conductance mechanisms and capsaicin and proton sensitivity are both regulated by the presence of NGF. Capsaicin has been shown to activate nociceptors via a specific membrane receptor which is blocked by the competitive antagonist, capsazepine [3, 16]....
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References
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