Journal ArticleDOI
Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis
Alexander Heyde,David Rohde,Cameron S. McAlpine,Shuang Zhang,Friedrich Felix Hoyer,Jeffrey M. Gerold,David Cheek,Yoshiko Iwamoto,Maximilian J. Schloss,Katrien Vandoorne,Oriol Iborra-Egea,Christian Muñoz-Guijosa,Antoni Bayes-Genis,Johannes G. Reiter,Morgan Craig,Filip K. Swirski,Matthias Nahrendorf,Martin A. Nowak,Kamila Naxerova +18 more
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TLDR
In this paper, the authors show that hematopoietic stem cell division rates are increased in mice and humans with atherosclerosis, and that increased stem cell proliferation expedites somatic evolution and expansion of clones with driver mutations.About:
This article is published in Cell.The article was published on 2021-03-04. It has received 114 citations till now. The article focuses on the topics: Hematopoietic stem cell proliferation & Hematopoietic stem cell.read more
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Targeting inflammation in atherosclerosis — from experimental insights to the clinic
TL;DR: Soehnlein et al. as discussed by the authors consider a gamut of attractive possibilities for modifying inflammation in atherosclerosis, including targeting pivotal inflammatory pathways such as the inflammasomes, inhibiting cytokines, manipulating adaptive immunity and promoting pro-resolution mechanisms.
Journal ArticleDOI
Atherosclerosis: Recent developments
Johan Björkegren,Aldons J. Lusis +1 more
TL;DR: A review of the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives, can be found in this paper .
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Social Determinants of Cardiovascular Disease
TL;DR: In this paper , an evidence-based framework for social determinants of health (SDoH), which encompass the economic, social, environmental, and psychosocial factors that influence health, is presented.
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Ageing and rejuvenation of tissue stem cells and their niches
TL;DR: A review of the cellular and molecular mechanisms underlying ageing in the regenerative regions of different tissues as well as potential rejuvenation strategies is presented in this paper , focusing primarily on brain, muscle and blood tissues.
Journal ArticleDOI
Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease
Christopher S. Marnell,Christopher S. Marnell,Alexander G. Bick,Pradeep Natarajan,Pradeep Natarajan +4 more
TL;DR: Clonal hematopoiesis of indeterminate potential (CHIP) is associated with a pro-inflammatory state that has been linked to coronary artery disease, myocardial infarction, and venous thromboembolic disease, as well as prognosis among those with aortic stenosis and heart failure.
References
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Journal ArticleDOI
Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
Siddhartha Jaiswal,Pierre Fontanillas,Jason Flannick,Jason Flannick,Alisa K. Manning,Peter V. Grauman,Brenton G. Mar,Brenton G. Mar,R. Coleman Lindsley,Craig H. Mermel,Noël P. Burtt,Alejandro Chavez,John M. Higgins,Vladislav Moltchanov,Vladislav Moltchanov,Frank C. Kuo,Michael J. Kluk,Brian E. Henderson,Leena Kinnunen,Heikki A. Koistinen,Heikki A. Koistinen,Claes Ladenvall,Gad Getz,Adolfo Correa,Benjamin F. Banahan,Stacey Gabriel,Stacey Gabriel,Sekar Kathiresan,Heather M. Stringham,Mark I. McCarthy,Michael Boehnke,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,Christopher A. Haiman,Leif Groop,Gil Atzmon,James G. Wilson,Donna Neuberg,David Altshuler,Benjamin L. Ebert +40 more
TL;DR: Age-related clonal hematopoiesis is a common condition that is associated with increases in the risk of hematologic cancer and in all-cause mortality, with the latter possibly due to an increased risk of cardiovascular disease.
Journal ArticleDOI
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
Journal ArticleDOI
Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
Giulio Genovese,Anna K. Kähler,Robert E. Handsaker,Johan Lindberg,Samuel A. Rose,Samuel F. Bakhoum,Kimberly Chambert,Eran Mick,Benjamin M. Neale,Menachem Fromer,Shaun Purcell,Oscar Svantesson,Mikael Landén,Martin Höglund,Sören Lehmann,Stacey Gabriel,Jennifer L. Moran,Eric S. Lander,Patrick F. Sullivan,Pamela Sklar,Henrik Grönberg,Christina M. Hultman,Steven A. McCarroll +22 more
TL;DR: Clonal hematopoiesis with somatic mutations is readily detected by means of DNA sequencing, is increasingly common as people age, and is associated with increased risks of hematologic cancer and death.
Journal ArticleDOI
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Simon Yona,Ki-Wook Kim,Yochai Wolf,Alexander Mildner,Diana Varol,Michal Breker,Dalit Strauss-Ayali,Sergey Viukov,Martin Guilliams,Alexander V. Misharin,David A. Hume,Harris Perlman,Bernard Malissen,Elazar Zelzer,Steffen Jung +14 more
TL;DR: A fate-mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression is reported, establishing that short-lived Ly6C(+) monocytes constitute obligatory steady-state precursors of blood-resident Ly 6C(-) cells and that the abundance of Ly6 C(+) blood monocytes dynamically controls the circulation lifespan of their progeny.
Journal ArticleDOI
Clonal Hematopoiesis and risk of atherosclerotic cardiovascular disease
Siddhartha Jaiswal,Pradeep Natarajan,Pradeep Natarajan,Alexander J. Silver,Christopher J. Gibson,Alexander G. Bick,Eugenia Shvartz,Marie McConkey,Namrata Gupta,Stacey Gabriel,Diego Ardissino,Usman Baber,Roxana Mehran,Valentin Fuster,Valentin Fuster,John Danesh,Philippe M. Frossard,Danish Saleheen,Olle Melander,Olle Melander,Galina K. Sukhova,Donna Neuberg,Peter Libby,Sekar Kathiresan,Benjamin L. Ebert +24 more
TL;DR: The presence of CHIP in peripheral‐blood cells was associated with nearly a doubling in the risk of coronary heart disease in humans and with accelerated atherosclerosis in mice.
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