Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain-derived neurotrophic factor expression.
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Cites background from "Individual differences in novelty s..."
...A recent report found that inactivation of hippocampal BDNF signaling by infusion of a BDNF scavenger induced social avoidance behavior after social defeat, whereas activation of hippocampal BDNF promoted social approach behavior (Duclot and Kabbaj 2013)....
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...Additional studies by our group identified differential changes in hippocampal gene expression between HR and LR rats exposed to social defeat in key genes such as CAM kinase II, Leptin, and importantly, BDNF, suggesting a neural basis for vulnerability to stress-induced depressive-like disorders (Duclot and Kabbaj 2013; Kabbaj et al. 2004)....
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...…changes in hippocampal gene expression between HR and LR rats exposed to social defeat in key genes such as CAM kinase II, Leptin, and importantly, BDNF, suggesting a neural basis for vulnerability to stress-induced depressive-like disorders (Duclot and Kabbaj 2013; Kabbaj et al. 2004)....
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153 citations
152 citations
Cites background from "Individual differences in novelty s..."
...In recent years, several animal studies (Duclot and Kabbaj, 2013; McEwen et al., 2015; Russo et al., 2012; Sandi and Richter-Levin, 2009) have revealed processes and mechanisms differentially altered in vulnerable individuals by stratifying subjects, as either vulnerable or resilient, based on a…...
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...(Duclot and Kabbaj, 2013; McEwen et al., 2015; Russo et al., 2012; Sandi and Richter-Levin, 2009) have revealed processes and mechan-...
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115 citations
85 citations
Cites background from "Individual differences in novelty s..."
...NADH CTATTAATCCCCGCCTGACC GGAGCTCGATTTGTTTCTGC Duclot and Kabbaj, 2013 Dnmt1 CAGATGTTCCATGCACACT TGTGGATGTAGGAAAGTTGCA Zhou et al., 2013 Dnmt3a ACGCCAAAGAAGTGTCTGCT CTTTGCCCTGCTTTATGGAG LaPlant et al., 2010 Dnmt3b TCACCCGAGAGACCAAGGAT CGTGATTCTGGGGGAGGTTC Own design Hprt1 GCAGACTTTGCTTTCCTTGG GTCTGGCCTGTATCCAACACT Sarkar et al., 2014 c-Fos ACCTCAAGGACTTGAAAGCATC ACATCTCCGGAAGAGGTGAG Echeverry-Alzate et al., 2012 c-Fos_Bis TAATTGTGAATATTTATAGGTGAAAGTTAT ACTCTATCCAATCTTCTCAATTACTAA Dyrvig et al., 2012 Bis, Bisulfite....
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...NADH CTATTAATCCCCGCCTGACC GGAGCTCGATTTGTTTCTGC Duclot and Kabbaj, 2013 Dnmt1 CAGATGTTCCATGCACACT TGTGGATGTAGGAAAGTTGCA Zhou et al., 2013 Dnmt3a ACGCCAAAGAAGTGTCTGCT CTTTGCCCTGCTTTATGGAG LaPlant et al., 2010 Dnmt3b TCACCCGAGAGACCAAGGAT CGTGATTCTGGGGGAGGTTC Own design Hprt1 GCAGACTTTGCTTTCCTTGG…...
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References
57,116 citations
"Individual differences in novelty s..." refers methods in this paper
...7 mm dorsoventral, relative to bregma (Paxinos and Watson, 1998)....
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...…apparatus, and bilaterally implanted with stainless steel guide cannulae aimed to the dentate gyrus (DG) using the following previously described coordinates (Carrier and Kabbaj, 2012): 4.3 mm anteroposterior, 3.0 mm lateral, and 3.7 mm dorsoventral, relative to bregma (Paxinos and Watson, 1998)....
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2,999 citations
"Individual differences in novelty s..." refers background or result in this paper
...In our study, LR rats, but not HR rats, exhibited a BDNF upregulation following social defeat, similar to the effects of antidepressants on BDNF expression (Duman and Monteggia, 2006), which suggested that the BDNF upregulation was mediating LR resilience....
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...In our study, LR rats, but not HR rats, exhibited a BDNF upregulation following social defeat, similar to the effects of antidepressants on BDNF expression (Duman and Monteggia, 2006), which suggested that the BDNF upregulation Figure 5....
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...In the hippocampus, most antidepressant treatments increase BDNF expression, which also exerts potent antidepressant effects by itself (Duman and Monteggia, 2006)....
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...Social defeat activates TrkB–Akt–CREB signaling pathway in LR rats, but not in HR rats In the hippocampus, most antidepressant treatments increase BDNF expression, which also exerts potent antidepressant effects by itself (Duman and Monteggia, 2006)....
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2,077 citations
"Individual differences in novelty s..." refers background in this paper
...els (Nibuya et al., 1995), which exerts antidepressant effects...
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...Moreover, classic antidepressants increase hippocampal BDNF levels (Nibuya et al., 1995), which exerts antidepressant effects (Shirayama et al., 2002; Hoshaw et al., 2005)....
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...Since antidepressants seem to have their beneficial effects through an increase in hippocampal BDNF contents (Nibuya et al., 1995; Shirayama et al., 2002; Yan et al., 2010), we hypothesized that the BDNF upregulation observed in LR animals following repeated social defeat is adaptive and mediates their behavioral resilience....
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...Since antidepressants seem to have their beneficial effects through an increase in hippocampal BDNF contents (Nibuya et al., 1995; Shirayama et al., 2002; Yan et al., 2010), we hypothesized that the BDNF upregulation observed in LR animals following repeated social defeat is adaptive and mediates…...
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1,873 citations
"Individual differences in novelty s..." refers methods in this paper
...One week after the last defeat session, the social avoidance (Berton et al., 2006) was measured as described previously (Duclot et al....
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...One week after the last defeat session, the social avoidance (Berton et al., 2006) was measured as described previously (Duclot et al., 2011)....
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1,863 citations