Journal ArticleDOI
Indolizidine and quinolizidine alkaloids
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This review covers the isolation, structure determination, synthesis, chemical transformations and biological activity of indolizidine and quinolIZidine alkaloids.About:
This article is published in Natural Product Reports.The article was published on 1994-01-01. It has received 281 citations till now. The article focuses on the topics: Quinolizidine & Indolizidine.read more
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Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
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Phosphine-triggered synthesis of functionalized cyclic compounds
Long-Wu Ye,Jian Zhou,Yong Tang +2 more
TL;DR: This tutorial review summarizes the recent achievements in nucleophilic phosphine catalysis and describes how phosphines can be easily tailored to efficient annulation reactions with good control over reaction selectivity.
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Organocatalytic Asymmetric Mannich Reactions: New Methodology, Catalyst Design, and Synthetic Applications
Amal Ting,Scott E. Schaus +1 more
TL;DR: In this paper, the authors present the methodology and synthetic advantages achieved so far in the asymmetric Mannich reaction, and present a Microreview of the recent contributions to this process.
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Biocatalytic Routes to Optically Active Amines
TL;DR: This review covers biocatalytic approaches using hydrolases (i.e. lipases, amidases), monoamine oxidase and other enzymes with special focus on the application of ω‐transaminases to allow efficient asymmetric synthesis starting from prostereogenic ketones.
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Compositional and nutritional evaluation of several lupin seeds.
TL;DR: White lupin was characterised by a higher essential amino acid index (EAAI) as well as chemical score (CS) of restrictive amino acids, and the highest protein efficiency ratio (PER), expressed in terms of the availability of leucine and tyrosine as compared to blue and yellow lupIn varieties.
References
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Journal ArticleDOI
Quinoline, quinazoline and acridone alkaloids
TL;DR: This review covers the isolation, structure determination, synthesis and biological activity of quinoline, quinazoline and acridone alkaloids from plant, microbial and animal sources.
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Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.
Rob A. Gruters,Jacques Neefjes,Matthijs Tersmette,Ruud E. Y. de Goede,Abraham Tulp,H. G. Huisman,Frank Miedema,Hidde L. Ploegh +7 more
TL;DR: The glucosidase inhibitors castanospermine and dNM, but not the mannosidase inhibitor dMM, inhibited syncytium formation and interfered with infectivity, suggesting involvement of N-linked glycans in the gp120–CD4 interaction.
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Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an ecuadoran poison frog
Thomas F. Spande,H. M. Garraffo,M. W. Edwards,Herman J. C. Yeh,Lewis K. Pannell,John W. Daly +5 more
TL;DR: A potent non-opioid analgesic, epibatidine, has been isolated from skins of the Ecuadoran poison frog, Epipedobates tricolor, and its structure determined by MS, IR, and 1 H NMR analyses as exo-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane represents a unique new class of alkaloids.
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The genetic polymorphism of debrisoquine/sparteine metabolism — Clinical aspects
TL;DR: The therapeutic implications for each of the classes of drugs affected by this genetic polymorphism in drug metabolism are discussed and it is emphasized that it is difficult to attain therapeutic plasma concentrations for some drugs in high activity extensive metabolizers.
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Further classification of skin alkaloids from neotropical poison frogs (dendrobatidae), with a general survey of toxic/noxious substances in the amphibia
TL;DR: Cutaneous granular glands are a shared character of adult amphibians, including caecilians, and are thought to be the source of most biologically active compounds in amphibian skin, which clearly prove the defensive value of these diverse metabolites.