Journal ArticleDOI
Indolizine: a biologically active moiety
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TLDR
The present review discusses the versatile nature of indolizine derivatives and their possible mechanism of action, and provides information about current/future prospects of the topic and different indolIZine derivatives in clinical trials.Abstract:
The discovery of camptothecin and its analogs was the major breakthrough through which “Indolizine moiety” came into limelight. Although major part of the research on indolizine derivatives is focused on anticancer drug discovery, these derivatives have also been screened for different biological activities such as antitubercular, antioxidant, antimicrobial, anticancer, and anti-inflammatory activities to name a few. Despite being an important medicinal moiety, a detailed review on the biologically active potential of indolizine derivative is unavailable. To the best of our knowledge, previous reviews on indolizine derivatives mainly focused on their chemistry and synthesis. The present review discusses the versatile nature of indolizine derivatives and their possible mechanism of action. Important SAR points are discussed with each study to highlight the rationale behind the study. Furthermore, the present review also provides information about current/future prospects of the topic and different indolizine derivatives in clinical trials.read more
Citations
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Journal ArticleDOI
Multicomponent syntheses of functional chromophores.
Lucilla Levi,Thomas Müller +1 more
TL;DR: This review encompasses the advances in the preparation of functional π-electron systems via multicomponent processes during the past few years, based both on the scaffold and chromophore concepts.
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Cu-catalyzed transannulation reaction of pyridotriazoles with terminal alkynes under aerobic conditions: efficient synthesis of indolizines
TL;DR: The Cu(I)-catalyzed denitrogenative transannulation reaction of pyridotriazoles with terminal alkynes en route to indolizines was developed and features aerobic conditions and much broader scope.
Journal ArticleDOI
Synthesis of 2-Aminoindolizines by 1,3-Dipolar Cycloaddition of Pyridinium Ylides with Electron-Deficient Ynamides
TL;DR: Electron-deficient ynamides, possessing an ynoate or an ynone moiety, have been successfully involved for the first time in a 1,3-dipolar cycloaddition with stabilized pyridinium ylides.
Journal ArticleDOI
Nucleophilic Dearomatization of Activated Pyridines
TL;DR: In this paper, the authors collected and summarized nucleophilic dearomatization reactions of pyridines reported in the literature between 2010 and mid-2018, complementing and updating previous reviews published in the early 2010s dedicated to various aspects of Pyridine chemistry.
Journal ArticleDOI
External-Photocatalyst-Free Visible-Light-Mediated Synthesis of Indolizines.
TL;DR: Investigation into the reaction mechanism indicates that the indolizine products themselves may be in some way involved in mediating and accelerating their own formation, and these simple heterocyclic compounds may be capable of facilitating other visible-light-mediated transformations.
References
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Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2
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The use of estrogens and progestins and the risk of breast cancer in postmenopausal women.
Graham A. Colditz,Susan E. Hankinson,David J. Hunter,Walter C. Willett,JoAnn E. Manson,Meir J. Stampfer,Charles H. Hennekens,Bernard Rosner,Frank E. Speizer +8 more
TL;DR: In this paper, the effect of adding progestins to estrogen therapy on the risk of breast cancer in postmenopausal women is investigated. But, the effect on the number of newly diagnosed invasive breast cancer cases was not quantified.
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The Role of Natural Product Chemistry in Drug Discovery
TL;DR: To continue to be competitive with other drug discovery methods, natural product research needs to continually improve the speed of the screening, isolation, and structure elucidation processes, as well addressing the suitability of screens for natural product extracts and dealing with issues involved with large-scale compound supply.