Journal ArticleDOI
Indomethacin-induced intestinal lesions in the rat.
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TLDR
A single large po or sc dose of indomethacin produced a high incidence of intestinal perforations 72 hr after administration to fed rats, and it appeared possible that there was a relationship between food intake, bile flow, and intestinal ulcers.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 1970-11-01. It has received 191 citations till now. The article focuses on the topics: Bile duct & Small intestine.read more
Citations
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Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans
TL;DR: The adverse effects of NSAIDs distal to the duodenum represent a range of pathologies that may be asymptomatic, but some are life threatening.
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Temporal Relationship Between Cyclooxygenase Inhibition, as Measured by Prostacyclin Biosynthesis, and the Gastrointestinal Damage Induced by Indomethacin in the Rat
TL;DR: Investigation of inhibition of cyclooxygenase in the rat small intestine and gastric mucosa after subcutaneous administration of indomethacin found no temporal relationship between prostaglandin inhibition and the formation of lesions in the small intestine since the lesions became macroscopically apparent and developed at a time when cyclo oxygengenase inhibition was already declining.
Journal ArticleDOI
Prostaglandins and the gastrointestinal mucosa: Are they important in its function, disease, or treatment?
TL;DR: The involvement of prostaglandins and related compounds in mucosal protection, in ulcer healing, in diarrhea, and in gastrointestinal inflammation is reviewed, with particular reference to the growing body of human data.
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Mitochondrial damage: a possible mechanism of the “topical” phase of NSAID induced injury to the rat intestine
S Somasundaram,S Rafi,Jeremy Hayllar,G Sigthorsson,M Jacob,A B Price,A Macpherson,T Mahmod,David Scott,J. M. Wrigglesworth,Ingvar Bjarnason +10 more
TL;DR: In vivo studies with nabumetone and aspirin suggested that uncoupling or inhibition of electron transport underlies the “topical” phase of NSAID induced damage.
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Mechanisms of acute and chronic intestinal inflammation induced by indomethacin
Tamaki Yamada,Edwin A. Deitch,Robert D. Specian,Michael A. Perry,R. Balfour Sartor,Matthew B. Grisham +5 more
TL;DR: It is concluded that a single injection of Indo produces acute intestinal mucosal injury and inflammation that resolve completely within three to seven days, whereas two daily injections of Indo produce both acute and chronic Injury and inflammation.
References
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Journal Article
Anti-inflammatory and antipyretic activities of indomethacin, 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid.
TL;DR: The compound is an active antipyretic drug, with potency 10 to 20 times that of phenylbutazone, and when used in conjunction with a steroid, the action of the latter is enhanced.
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A Study of the Factors Involved in the Production of Gastric Ulcers by the Restraint Technique
David A. Brodie,Harley M. Hanson +1 more
TL;DR: Six species of experimental animals were tested for the production of gastric ulcers by restraining the animals in wire screen for 24 hours, and rumen ulcers were produced by this procedure.
Journal Article
Studies on the absorption, distribution and excretion of indomethacin in various species
TL;DR: Indomethacin is promptly and completely absorbed after oral administration, and the half-life of the drug in plasma varies among species, ranging from 20 min to 4 hr, and most of the dose is eliminated from the body in 24 hr, the route of excretion varying among species.
Journal Article
Small intestinal ulcers and intestinal flora in rats given indomethacin.
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