Induced protein degradation: an emerging drug discovery paradigm
Citations
12 citations
12 citations
Cites background from "Induced protein degradation: an eme..."
...The newly developed proteolysis targeting chimera (PROTAC) protein degradation technology plays a significant part in modern anticancer drug design (Lai and Crews, 2017)....
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...However, PROTACs are made up of two small molecules, which is an inherent disadvantage because the molecular weight is usually large and pharmacokinetic data as well as drug-forming properties are poor (Lai and Crews, 2017)....
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12 citations
12 citations
Cites background from "Induced protein degradation: an eme..."
...…various E3 ligases and DUBs are being evaluated as potential drug targets for either protein targeting chimeras (PROTACs) or inhibitors, respectively, due to their proven ability to specifically target cellular protein homeostasis (Huang and Dixit, 2016; Lai and Crews, 2017; Harrigan et al., 2018)....
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...Consequently, various E3 ligases and 40 DUBs are being evaluated as potential drug targets for either protein targeting chimeras (PROTACs) or 41 inhibitors, respectively, due to their proven ability to specifically target cellular protein homeostasis (Huang 42 and Dixit, 2016; Lai and Crews, 2017; Harrigan et al., 2018)....
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11 citations
References
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