Induction Chemotherapy Followed by Either Chemoradiotherapy or Bioradiotherapy for Larynx Preservation: The TREMPLIN Randomized Phase II Study
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...Both treatments were associated with substantial toxicity, and the dropout rate from severe or life-threatening toxicity encountered with induction docetaxel plus cisplatin and 5-fluorouracil was unacceptably high.(50) To define a role for IC, trials were designed to compare induction with taxane, cisplatin, and 5-fluorouracil followed by chemoradiation to chemoradiation alone....
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Cites background or methods from "Induction Chemotherapy Followed by ..."
...A takeaway from this trial was that treatment delivery for either arm was difficult after induction therapy.(73) A recent Italian study also examined cetuximab versus cisplatin concurrent with XRT for locally advanced SCCHN....
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...Table 1 summarizes the data from the larynx preservation trials.(40,66,67,73) Regardless of the specific etiology accountable for the worse OS, patient selection for laryngeal preservation must be better refined, such that the risks and benefits of each therapy are carefully weighed....
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