Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production
Citations
165 citations
Cites background from "Induction of Airway Mucus Productio..."
...In murine asthma models using IL-4-deficient (IL-4 ) mice, IL-4 has been found important for both eosinophil (37) and Th2 cell (38) recruitment to the lungs, and Th2 cell production of IL-4 is necessary for the development of airway eosinophilia (39)....
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164 citations
Cites background from "Induction of Airway Mucus Productio..."
...Recently, effector CD4 T cells are recognized to play dominant roles in initiating allergic pulmonary inflammation, because adoptive transfer of Ag-specific Th2 cells, not Th1 cells, into naive mice followed by aerosol challenge of Ag caused AHR, eosinophilia, and mucus secretion with recruitment of Th2 cells into the allergic lung (41)....
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162 citations
Cites background from "Induction of Airway Mucus Productio..."
...Adoptive transfer of Ag-specific Th2 cells derived from IL-4-deficient mice still induced airway hyperresponsiveness (AHR)(3) and overproduction of mucus (6, 7)....
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160 citations
Cites background from "Induction of Airway Mucus Productio..."
...Alternatively, the reduced production of IL-4 by ITK null T cells may underlie their lack of significant Ag-specific recruitment to the lung since IL-4 null TH2 cells have been reported to be defective in this process (50)....
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159 citations
References
7,567 citations
"Induction of Airway Mucus Productio..." refers background in this paper
...The lower limit of sensitivity for each of the ELISAs was 0.6 ng/ml (IFNg ), 5 pg/ml (IL-4), 0.010 ng/ml (IL-5), and 200 pg/ml (IL-10)....
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...CD4 Th2 cells make a different panel of cytokines, including IL-4, IL-5, and IL-10 (17, 18)....
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...Assays were standardized with recombinant IFNg , IL-5, IL-10 (Endogen), and IL-4 (Collaborative Research, Inc.)....
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...1 A ), and IL-10 (data not shown)....
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...IL-4 2/2 OVA-specific Th2 cells produced comparable levels of IL-5 and IL-10 when compared to IL-4 1/1 OVA-specific Th2 cells, but IL-4 was produced only by IL-4 1/1 Th2 cells....
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2,898 citations
"Induction of Airway Mucus Productio..." refers background in this paper
...Th2 cells secreting IL-4 and IL-5 have been shown to be present and activated in the bronchial wall of asthmatic individuals (9, 23)....
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1,916 citations
"Induction of Airway Mucus Productio..." refers methods in this paper
...To generate Th1 or Th2 cells from DO11.10 mice, CD4 T cells were isolated by negative selection as previously described (31) using mAbs to CD8 (clone 53-6.72, clone 2.43 [ 32 ]), Class II MHC I-A d (212.A1 [33]) and anti‐Ig-coated magnetic beads (Advanced Magnetics, Inc....
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1,831 citations
1,262 citations