Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production
Citations
45 citations
Cites background from "Induction of Airway Mucus Productio..."
...The proliferation of these mucus-containing epithelial cells has been shown (1) to be intimately linked to T helper type 2 (Th2)-mediated inflammation in response to aeroallergen exposure, and studies have implicated specific roles for the Th2 cytokines interleukin-4 (IL-4) (7), IL-9 (40), and IL-13 (18) as proinflammatory mediators linked to the induction of mucus production....
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...(6, 7) have demonstrated, through a series of adoptive transfer studies, that CD4 T cells of the Th2 subset and signaling through IL-4 receptor -subunit have significant roles in mucus production, although IL-4 expression is not required....
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45 citations
45 citations
Cites background from "Induction of Airway Mucus Productio..."
...J Exp Med 186, 1737-1747 111 Brusselle, G. et al. (1995) Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice....
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...J Exp Med 186, 1737-1747 111 Brusselle, G. et al. (1995) Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice. Am J Respir Cell Mol Biol 12, 254-259 112 Hogan, S.P. et al. (1998) A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5....
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44 citations
44 citations
References
7,567 citations
"Induction of Airway Mucus Productio..." refers background in this paper
...The lower limit of sensitivity for each of the ELISAs was 0.6 ng/ml (IFNg ), 5 pg/ml (IL-4), 0.010 ng/ml (IL-5), and 200 pg/ml (IL-10)....
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...CD4 Th2 cells make a different panel of cytokines, including IL-4, IL-5, and IL-10 (17, 18)....
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...Assays were standardized with recombinant IFNg , IL-5, IL-10 (Endogen), and IL-4 (Collaborative Research, Inc.)....
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...1 A ), and IL-10 (data not shown)....
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...IL-4 2/2 OVA-specific Th2 cells produced comparable levels of IL-5 and IL-10 when compared to IL-4 1/1 OVA-specific Th2 cells, but IL-4 was produced only by IL-4 1/1 Th2 cells....
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2,898 citations
"Induction of Airway Mucus Productio..." refers background in this paper
...Th2 cells secreting IL-4 and IL-5 have been shown to be present and activated in the bronchial wall of asthmatic individuals (9, 23)....
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1,916 citations
"Induction of Airway Mucus Productio..." refers methods in this paper
...To generate Th1 or Th2 cells from DO11.10 mice, CD4 T cells were isolated by negative selection as previously described (31) using mAbs to CD8 (clone 53-6.72, clone 2.43 [ 32 ]), Class II MHC I-A d (212.A1 [33]) and anti‐Ig-coated magnetic beads (Advanced Magnetics, Inc....
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1,831 citations
1,262 citations