Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production
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Cites background from "Induction of Airway Mucus Productio..."
...Activated Th2 cells produce a series of cytokines, including IL-4, IL-5 and IL-10 (Mosmann et al., 1986; Cohn et al., 1997)....
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6 citations
Cites background from "Induction of Airway Mucus Productio..."
...For instance, these works disagree on the ability of the individual COX isoforms to prevent AHR....
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...This test is designed to identify AHR following challenge of the airways with a common bronchoconstrictor, such as methacholine, 2 which is reversible upon treatment with a bronchodilator....
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...Adoptive transfer of allergen-specific TH2 cells into naïve animals prior to antigen challenge can initiate eosinophil recruitment, increased mucus production, and AHR (124, 125), underscoring the critical contribution of these cells and their cytokines to lung allergy....
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...Data generated in our lab suggests that although loss of the TP -/- receptor does not alter pulmonary inflammation, a TP-agonist induces bronchoconstriction in naïve animals and AHR in the inflamed murine airway (301)....
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...143 xii LIST OF ABBREVIATIONS 129 129S6/SvEv AA Arachidonic acid AERD Aspirin-exacerbated respiratory disease Alum Aluminum hydroxide AM Alveolar macrophage AHR Airway hyperresponsiveness APC Antigen presenting cell ASM Airway smooth muscle...
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6 citations
Cites background from "Induction of Airway Mucus Productio..."
...Investigations in mouse models showed that cell transfer and overexpression of Th2 cytokines in murine airway epithelial cells lead to asthma symptoms such as increased secretion of mucus, AHR and eosinophilia [65, 66]....
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References
7,567 citations
"Induction of Airway Mucus Productio..." refers background in this paper
...The lower limit of sensitivity for each of the ELISAs was 0.6 ng/ml (IFNg ), 5 pg/ml (IL-4), 0.010 ng/ml (IL-5), and 200 pg/ml (IL-10)....
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...CD4 Th2 cells make a different panel of cytokines, including IL-4, IL-5, and IL-10 (17, 18)....
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...Assays were standardized with recombinant IFNg , IL-5, IL-10 (Endogen), and IL-4 (Collaborative Research, Inc.)....
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...1 A ), and IL-10 (data not shown)....
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...IL-4 2/2 OVA-specific Th2 cells produced comparable levels of IL-5 and IL-10 when compared to IL-4 1/1 OVA-specific Th2 cells, but IL-4 was produced only by IL-4 1/1 Th2 cells....
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2,898 citations
"Induction of Airway Mucus Productio..." refers background in this paper
...Th2 cells secreting IL-4 and IL-5 have been shown to be present and activated in the bronchial wall of asthmatic individuals (9, 23)....
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1,916 citations
"Induction of Airway Mucus Productio..." refers methods in this paper
...To generate Th1 or Th2 cells from DO11.10 mice, CD4 T cells were isolated by negative selection as previously described (31) using mAbs to CD8 (clone 53-6.72, clone 2.43 [ 32 ]), Class II MHC I-A d (212.A1 [33]) and anti‐Ig-coated magnetic beads (Advanced Magnetics, Inc....
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1,831 citations
1,262 citations