Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production
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...Multiple lines of evidence suggest that allergen-specific CD4+ Th2 cells play an essential role in initiating and generating these abnormalities (8, 17, 27)....
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...For example, in experiments using passively transferred in vitro polarized and activated Th2 cells, IL-4 plays an important role in T-cell recruitment from the vascular space and the migration of eosinophils from the lung into the airway, but it cannot account for the ability of Th2 cells to stimulate mucus elaboration or induce AHR to methacholine (17, 18)....
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"Induction of Airway Mucus Productio..." refers background in this paper
...It has also been suggested that eosinophils, by damaging the bronchial epithelium and exposing the bronchial wall to more chemical stimuli, increase neural-mediated mechanisms of mucus secretion (47)....
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...These studies show the critical role of inflammation in mucus hypersecretion and confirms observations in a variety of human diseases, including asthma, that lung inflammation is necessary for mucus production (47)....
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