Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production
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...Multiple lines of evidence suggest that allergen-specific CD4+ Th2 cells play an essential role in initiating and generating these abnormalities (8, 17, 27)....
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...For example, in experiments using passively transferred in vitro polarized and activated Th2 cells, IL-4 plays an important role in T-cell recruitment from the vascular space and the migration of eosinophils from the lung into the airway, but it cannot account for the ability of Th2 cells to stimulate mucus elaboration or induce AHR to methacholine (17, 18)....
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"Induction of Airway Mucus Productio..." refers background or methods in this paper
...OVA-specific Th2 cells from IL-4–deficient (IL-4 2/2) mice or wild-type (IL-4 1/1) BALB/c mice were generated as has been described previously (41, 43)....
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...The transferred cells maintained their commitment to the secretion of Th1 or Th2 cytokines in response to OVA as has been described previously (41)....
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...Using a standard procedure to polarize CD4 T cell responses (41), splenic CD4 T cells were stimulated by pOVA 323-339 in the presence of IL-12, IL-2, and anti–IL-4 to induce Th1-like cells or IL-4, IL-2, and anti–IFNg to induce Th2-like cells....
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