Induction of apoptosis and activation of NF-κB by CD95 require different signalling thresholds
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...Anteriormente, se ha descrito que la estimulación de FAS conlleva la activación de las rutas de las MAPK y de NF-kB en diferentes procesos relacionados con el crecimiento de neuritas [151], progresión de tumores [152], en progenitores de células del sistema nervioso [153], o en linfocitos de pacientes con ALPS y esplenocitos de ratones lpr/gld [154]....
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...Concretamente, en el trabajo realizado con ratones lpr [154], se analizó la activación de NF-kB en esplenocitos tratados con FAS-L tras una estimulación incompleta con anti-CD3 y una breve expansión con IL-2....
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Cites background from "Induction of apoptosis and activati..."
...In these cells, it was shown that CD95L treatment triggers the activation of non-apoptotic kinase pathways such as NFκB and MAPK pathways (Barnhart et al., 2004; Legembre et al., 2004a, 2004b)....
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References
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"Induction of apoptosis and activati..." refers background in this paper
...Mutations in the DD have been shown to abrogate induction of apoptosis (Fisher et al, 1995)....
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1,194 citations
"Induction of apoptosis and activati..." refers background in this paper
...Mutations in the DD of CD95 are naturally found both in mice (lprcg mice; Kimura & Matsuzawa, 1994) and in many patients suffering from autoimmune lymphoproliferative syndrome (ALPS) type Ia (Rieux-Laucat et al, 1995, 1999; Drappa et al, 1996; Martin et al, 1999; Straus et al, 2001)....
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1,193 citations
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"Induction of apoptosis and activati..." refers background in this paper
...On binding of CD95 ligand (CD95L), CD95 recruits the adaptor protein FADD, the initiator caspases 8 and 10 and the apoptosis regulator c-FLIP, forming the death-inducing signalling complex (DISC; Peter & Krammer, 2003)....
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693 citations
"Induction of apoptosis and activati..." refers background in this paper
...&2004 EUROPEAN MOLECULAR BIOLOGY ORGANIZATION EMBO reports VOL 5 | NO 11 | 2004 scientificreport 1085 wild-type receptors (Siegel et al, 2000)....
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