Induction of apoptosis and activation of NF-κB by CD95 require different signalling thresholds
Citations
32 citations
32 citations
Cites background from "Induction of apoptosis and activati..."
...The increased predisposition may result from differential signaling thresholds for heterozygous Fas mutations, with continued Fas-dependent signaling promoting growth despite impaired apoptosis induction [62]....
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28 citations
28 citations
Cites background from "Induction of apoptosis and activati..."
...Recently, we questioned this dogma when we found that cells expressing a heterozygous death domain–mutated Fas could still transduce nonapoptotic signals (29)....
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27 citations
Cites background from "Induction of apoptosis and activati..."
...Third, in the report showing that lpr mutant is partially functional, the authors clearly demonstrated that lpr mutant completely loses the capacity to induce cell death while it can activate NF- B signaling only in heterozygous (lpr/ ) mice (40)....
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...Although lpr mutation does not completely eliminate Fas signaling (40), it is unlikely that the mutant Fas still delivers a critical death signal during TCR-induced cell death in our system based on three lines of evidences....
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References
1,472 citations
"Induction of apoptosis and activati..." refers background in this paper
...Mutations in the DD have been shown to abrogate induction of apoptosis (Fisher et al, 1995)....
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1,194 citations
"Induction of apoptosis and activati..." refers background in this paper
...Mutations in the DD of CD95 are naturally found both in mice (lprcg mice; Kimura & Matsuzawa, 1994) and in many patients suffering from autoimmune lymphoproliferative syndrome (ALPS) type Ia (Rieux-Laucat et al, 1995, 1999; Drappa et al, 1996; Martin et al, 1999; Straus et al, 2001)....
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1,193 citations
1,096 citations
"Induction of apoptosis and activati..." refers background in this paper
...On binding of CD95 ligand (CD95L), CD95 recruits the adaptor protein FADD, the initiator caspases 8 and 10 and the apoptosis regulator c-FLIP, forming the death-inducing signalling complex (DISC; Peter & Krammer, 2003)....
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693 citations
"Induction of apoptosis and activati..." refers background in this paper
...&2004 EUROPEAN MOLECULAR BIOLOGY ORGANIZATION EMBO reports VOL 5 | NO 11 | 2004 scientificreport 1085 wild-type receptors (Siegel et al, 2000)....
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