Induction of apoptosis and activation of NF-κB by CD95 require different signalling thresholds
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Cites background from "Induction of apoptosis and activati..."
...There is increasing evidence for dual Fas signaling in several different cell systems and the signaling outcome appears to depend on several factors, including the threshold of activation (32) and the interplay of environmental factors....
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...There are several suggested candidates for inducing Fas Agmediated NF- B activation, including the MAPK cascade (32)....
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Cites background from "Induction of apoptosis and activati..."
...Another possibility would be that in heterozygous ALPS-Ia patients in which apoptotic Fas signaling is abolished, this alternative signal transduction pathway was maintained, such as it has been described for the activation of NF- B [46], while the homozygous mutation in FasL observed in the ALPS-Ic patient would completely abolish all signal transduction due to Fas ligation....
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References
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"Induction of apoptosis and activati..." refers background in this paper
...Mutations in the DD have been shown to abrogate induction of apoptosis (Fisher et al, 1995)....
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1,194 citations
"Induction of apoptosis and activati..." refers background in this paper
...Mutations in the DD of CD95 are naturally found both in mice (lprcg mice; Kimura & Matsuzawa, 1994) and in many patients suffering from autoimmune lymphoproliferative syndrome (ALPS) type Ia (Rieux-Laucat et al, 1995, 1999; Drappa et al, 1996; Martin et al, 1999; Straus et al, 2001)....
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1,193 citations
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"Induction of apoptosis and activati..." refers background in this paper
...On binding of CD95 ligand (CD95L), CD95 recruits the adaptor protein FADD, the initiator caspases 8 and 10 and the apoptosis regulator c-FLIP, forming the death-inducing signalling complex (DISC; Peter & Krammer, 2003)....
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693 citations
"Induction of apoptosis and activati..." refers background in this paper
...&2004 EUROPEAN MOLECULAR BIOLOGY ORGANIZATION EMBO reports VOL 5 | NO 11 | 2004 scientificreport 1085 wild-type receptors (Siegel et al, 2000)....
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