Induction of apoptosis and activation of NF-κB by CD95 require different signalling thresholds
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Cites background from "Induction of apoptosis and activati..."
...In contrast, the signaling threshold to activate NF- B is significantly lower and can be achieved even in the presence of only one functional Fas allele (74)....
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...This advantage is likely due to the fact that Fas-induced apoptosis requires two functional Fas alleles in order to ensure efficient DISC formation (74)....
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406 citations
Cites background from "Induction of apoptosis and activati..."
...This advantage could be explained by the evidence that Fas-induced apoptosis requires two functional Fas alleles to ensure efficient DISC formation, whereas, in contrast, only one functional allele is sufficient to activate NF- B and promote cell survival (158)....
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279 citations
References
481 citations
"Induction of apoptosis and activati..." refers background in this paper
...Mutations in the DD of CD95 are naturally found both in mice (lprcg mice; Kimura & Matsuzawa, 1994) and in many patients suffering from autoimmune lymphoproliferative syndrome (ALPS) type Ia (Rieux-Laucat et al, 1995, 1999; Drappa et al, 1996; Martin et al, 1999; Straus et al, 2001)....
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435 citations
348 citations
"Induction of apoptosis and activati..." refers background in this paper
...Activation of NF-kB promotes tumour growth through transcriptional activation of a number of target genes that exert proliferative, antiapoptotic and/or tumorigenic functions (Lin & Karin, 2003)....
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322 citations
"Induction of apoptosis and activati..." refers background or result in this paper
...Our findings on the lack of activation of Erk1/2 in cells expressing two CD95 mutant alleles differ from those in a study that reported that in certain neurons from lprcg/lprcg mice, triggering of CD95 can still activate Erk1/2 (Desbarats et al, 2003)....
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...Using an enzyme-linked immunosorbent assay (ELISA) specific for p65, EMSA and western blot analysis, we documented the activation of NF-kB, Erk1/2 and p38 in cells from both wild-type and wt/lprcg mice, but not in cells from lprcg/lprcg mice (Fig 3B,C and supplementary Fig 2A online)....
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...We now demonstrate that cells carrying heterozygous mutations in the CD95 DD are deficient in induction of apoptosis but can still efficiently activate the transcription factor NF-kB and the MAP kinases Erk1/2 and p38....
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...In addition to serving a critical role in mediating lymphocyte apoptosis, stimulation of CD95 has been shown to result in activation of the transcription factor nuclear factor-kB (NF-kB) and of mitogen-activated protein (MAP) kinases (Desbarats et al, 2003; Wajant et al, 2003)....
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309 citations
"Induction of apoptosis and activati..." refers methods in this paper
...MCF-7 cells were transfected with an HIV-kB-CAT reporter plasmid driven by the kB sites in the HIV LTR (Franzoso et al, 1992) using Polyfect from Qiagen (Maryland, USA) according to the manufacturer’s protocols....
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