Induction of apoptosis and activation of NF-κB by CD95 require different signalling thresholds
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Cites background from "Induction of apoptosis and activati..."
...In contrast, the signaling threshold to activate NF- B is significantly lower and can be achieved even in the presence of only one functional Fas allele (74)....
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...This advantage is likely due to the fact that Fas-induced apoptosis requires two functional Fas alleles in order to ensure efficient DISC formation (74)....
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406 citations
Cites background from "Induction of apoptosis and activati..."
...This advantage could be explained by the evidence that Fas-induced apoptosis requires two functional Fas alleles to ensure efficient DISC formation, whereas, in contrast, only one functional allele is sufficient to activate NF- B and promote cell survival (158)....
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"Induction of apoptosis and activati..." refers background in this paper
...As chronic activation of NF-kB in lymphoid cells contributes to lymphomagenesis (Ruland & Mak, 2003), the stimulation of mutant CD95 in ALPS type Ia patients associated with enhanced CD95L expression could further increase the risk of lymphoma....
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42 citations
"Induction of apoptosis and activati..." refers background in this paper
...Mutations in the DD of CD95 are naturally found both in mice (lprcg mice; Kimura & Matsuzawa, 1994) and in many patients suffering from autoimmune lymphoproliferative syndrome (ALPS) type Ia (Rieux-Laucat et al, 1995, 1999; Drappa et al, 1996; Martin et al, 1999; Straus et al, 2001)....
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10 citations
"Induction of apoptosis and activati..." refers methods in this paper
...C3H lprcg mice (Yasuda et al, 2000) were bred with C3H wild-type mice (Jackson Laboratories, Bar Harbor, ME, USA) to generate heterozygous mice....
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