Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
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Cites background from "Induction of endothelial PAS domain..."
...Despite the prominent expression of HIF-2a in the vascular endothelium of wild-type mice, Epas12/2 mice have no obvious vascular defects, suggesting that HIF-1a expression in these cells (75) may be sufficient for normal development....
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...1) are highly conserved in HIF-2a (49, 67, 73)....
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...However, the role of HIF-2a in vascular development within specific organs, such as the lung (11), warrants further study....
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...Together, these findings suggest the possibility that HIF-1a (as well as HIF-2a, HIF-3a, and other class II bHLH-PAS proteins) may bind a cofactor through which the biological activity of the transcription factor could be modulated....
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...Renal carcinoma cell lines, which lack expression of the von Hipple-Lindau (VHL) tumor suppressor protein, maximally express HIF-1a and HIF-2a under nonhypoxic conditions and O2-regulated expression is restored in cells that have been transfected with a VHL expression vector (47)....
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