Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
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...Naive CD4(1) T cells were cultured under Treg-cell-inducing condition in the absence (2) or presence (1) of butyrate....
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Cites background from "Induction of Intestinal Th17 Cells ..."
...Aside from the direct influence of the microbiota on the immune machinery associated with the induction of oral tolerance, commensalspecific Treg can promote class switching to IgA in an antigenspecific manner (Cong et al., 2009; Tsuji et al., 2009), thereby controlling the host relationship with the microbiota via multiple mechanisms (Peterson et al., 2007; Suzuki et al., 2004) (Figure 2)....
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...Indeed, established IgA-producing clones are outcompeted by novel antibacterial responses, allowing the mucosal immune system to respond to a constantly changing microbiota (Hapfelmeier et al., 2010)....
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...IgA specific for commensals is produced with the help of intestinal dendritic cells that sample commensals associated with the epithelium and interact with B and T cells in the Peyer’s patches to produce IgA specific for commensal-derived antigens (Macpherson and Uhr, 2004)....
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...Compartmentalization of intestinal bacteria also depends on secreted immunoglobulin A (IgA)....
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...Indeed, colostrum and breast milk contain live microbes, metabolites, IgA, and immune cells as well as cytokines....
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References
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"Induction of Intestinal Th17 Cells ..." refers methods in this paper
...For enrichment analysis of biological process ontology, probe lists were analyzed in DAVID (Dennis et al., 2003; Huang da et al., 2009) and processes were selected based on p values smaller than 0.01....
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10,126 citations
"Induction of Intestinal Th17 Cells ..." refers background in this paper
...488 Cell 139, 485–498, October 30, 2009 ª2009 Elsevier Inc....
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...Error bars represent the SD. 492 Cell 139, 485–498, October 30, 2009 ª2009 Elsevier Inc. Turnbaugh et al., 2006), but they also have profound effects on the host immune system (Cash et al., 2006; Macpherson and Harris, 2004)....
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...Error bars represent the SD. Cell 139, 485–498, October 30, 2009 ª2009 Elsevier Inc. 491 growth of C. rodentium than were noncohoused mice, as demonstrated by recovery of infectious units from the wall of the colon (Figure 7A)....
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...Error bars represent the SD. Cell 139, 485–498, October 30, 2009 ª2009 Elsevier Inc. 489 (Figure 5B)....
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...Cell 139, 485–498, October 30, 2009 ª2009 Elsevier Inc. 487 intentionally introduced into Jackson Laboratory animals....
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"Induction of Intestinal Th17 Cells ..." refers background in this paper
...…growth factor b (TGF-b) for their differentiation and are defined by the expression of the lineage-specific transcription factors RORgt and Foxp3, respectively (Fontenot et al., 2003; Hori et al., 2003; Ivanov et al., 2006; Khattri et al., 2003; Mangan et al., 2006; Veldhoen et al., 2006)....
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...Th17 and Treg cells are both dependent on transforming growth factor b (TGF-b) for their differentiation and are defined by the expression of the lineage-specific transcription factors RORgt and Foxp3, respectively (Fontenot et al., 2003; Hori et al., 2003; Ivanov et al., 2006; Khattri et al., 2003; Mangan et al., 2006; Veldhoen et al., 2006)....
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7,321 citations
"Induction of Intestinal Th17 Cells ..." refers background in this paper
...…growth factor b (TGF-b) for their differentiation and are defined by the expression of the lineage-specific transcription factors RORgt and Foxp3, respectively (Fontenot et al., 2003; Hori et al., 2003; Ivanov et al., 2006; Khattri et al., 2003; Mangan et al., 2006; Veldhoen et al., 2006)....
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...Th17 and Treg cells are both dependent on TGF-β for their differentiation and are defined by the expression of the lineage-specific transcription factors RORγt and Foxp3, respectively (Fontenot et al., 2003; Hori et al., 2003; Ivanov et al., 2006; Khattri et al., 2003; Mangan et al., 2006)(Veldhoen et al....
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